A fundamental function of the intestinal epithelium is to act as a barrier that limits interactions
between luminal contents such as the intestinal microbiota, the underlying immune system …

The monolayer of endothelial cells lining the vessel wall forms a semipermeable barrier (in
all tissue except the relatively impermeable blood–brain and inner retinal barriers) that …

Evidence from physical sciences in oncology increasingly suggests that the interplay
between the biophysical tumor microenvironment and genetic regulation has significant …

Early atherosclerosis features functional and structural changes in the endothelial barrier
function that affect the traffic of molecules and solutes between the vessel lumen and the …

The existence of orderly structures, such as tissues and organs is made possible by cell
adhesion, ie, the process by which cells attach to neighbouring cells and a supporting …

INTRODUCTION Cadherins are an ancient class of transmembrane proteins that are
essential for the formation of multicellular tissues in metazoans. Cadherins link intercellular …

During epithelial morphogenesis, E-cadherin adhesive junctions play an important part in
mechanically coupling the contractile cortices of cells together, thereby distributing the …

Cell-cell adhesions are critical for the development and maintenance of tissues. Present at
sites of cell-cell contact are the adherens junctions and tight junctions. The adherens …

Control of cell number is crucial in animal development and tissue homeostasis, and its
dysregulation may result in tumor formation or organ degeneration. The Hippo pathway in …

Life is characterized by a myriad of complex dynamic processes allowing organisms to grow,
reproduce, and evolve. Physical approaches for describing systems out of thermodynamic …