Overview of the 2022 WHO classification of thyroid neoplasms

ZW Baloch, SL Asa, JA Barletta, RA Ghossein… - Endocrine …, 2022 - Springer
This review summarizes the changes in the 5th edition of the WHO Classification of
Endocrine and Neuroendocrine Tumors that relate to the thyroid gland. The new …

A robust unsupervised machine-learning method to quantify the morphological heterogeneity of cells and nuclei

JM Phillip, KS Han, WC Chen, D Wirtz, PH Wu - Nature protocols, 2021 - nature.com
Cell morphology encodes essential information on many underlying biological processes. It
is commonly used by clinicians and researchers in the study, diagnosis, prognosis, and …

[HTML][HTML] Updates in the pathologic classification of thyroid neoplasms: a review of the World Health Organization classification

Y Bai, K Kakudo, CK Jung - Endocrinology and Metabolism, 2020 - synapse.koreamed.org
Advances in medical sciences and evidence-based medicine have led to momentous
changes in classification and management of thyroid neoplasms. Much progress has been …

Deep learning prediction of BRAF-RAS gene expression signature identifies noninvasive follicular thyroid neoplasms with papillary-like nuclear features

JM Dolezal, A Trzcinska, CY Liao, S Kochanny… - Modern …, 2021 - nature.com
Noninvasive follicular thyroid neoplasms with papillary-like nuclear features (NIFTP) are
follicular-patterned thyroid neoplasms defined by nuclear atypia and indolent behavior. They …

Detection of NTRK1/3 Rearrangements in Papillary Thyroid Carcinoma Using Immunohistochemistry, Fluorescent In Situ Hybridization, and Next-Generation …

YC Lee, JY Chen, CJ Huang, HS Chen, AH Yang… - Endocrine …, 2020 - Springer
NTRK1/3 rearrangements have been reported in 2.3–3.4% of papillary thyroid carcinoma
(PTC) and are regarded as potential therapeutic targets. Recently, the application of …

A panel of plasma exosomal miRNAs as potential biomarkers for differential diagnosis of thyroid nodules

M Liang, S Yu, S Tang, L Bai, J Cheng, Y Gu, S Li… - Frontiers in …, 2020 - frontiersin.org
Background: A liquid biopsy using circulating exosomal genetic materials provides new
insights for thyroid cancer diagnosis. This study aimed to identify plasma-derived exosomal …

A comprehensive study on the diagnosis and management of noninvasive follicular thyroid neoplasm with papillary-like nuclear features

BA Alzumaili, LN Krumeich, R Collins, T Kravchenko… - Thyroid, 2023 - liebertpub.com
Background: Since the noninvasive follicular thyroid neoplasm with papillary-like nuclear
features (NIFTPs) was introduced in 2016, most retrospective studies have included cases …

Non-invasive follicular thyroid neoplasm with papillary-like nuclear features is not a cytological diagnosis, but it influences cytological diagnosis outcomes: a …

E Haaga, D Kalfert, M Ludvíková, I Kholová - Acta Cytologica, 2022 - karger.com
Background: A low-risk thyroid tumour, non-invasive follicular thyroid neoplasm with
papillary-like nuclear features (NIFTP) was introduced in 2016. NIFTP criteria require a …

Immunohistochemical biomarkers in thyroid pathology

Z Baloch, O Mete, SL Asa - Endocrine pathology, 2018 - Springer
The application of immunohistochemistry to the diagnosis of thyroid lesions has increased
as new biomarkers have emerged. In this review, we discuss the biomarkers that are critical …

[HTML][HTML] Clinical utility of EZH1 mutations in the diagnosis of follicular-patterned thyroid tumors

CK Jung, Y Kim, S Jeon, K Jo, S Lee, JS Bae - Human Pathology, 2018 - Elsevier
Follicular-patterned tumors of the thyroid gland are characterized by a predominantly
follicular growth pattern. They frequently harbor RAS mutations, not BRAF mutations …