Osteosarcoma (OS) is the most frequent primary bone cancer in children and adolescents
and the third most frequent in adults. Many inherited germline mutations are responsible for …

Retinoblastoma management remains complex, requiring individualized treatment based on
International Classification of Retinoblastoma (ICRB) staging, germline mutation status …

Background Osteosarcoma is the most common primary bone malignancy. As a rare cancer,
population‐based studies remain small with limited information on finer demographic …

Background Most patients with path_MMR gene variants (Lynch syndrome (LS)) now
survive both their first and subsequent cancers, resulting in a growing number of older …

Clinical outcomes and treatment modalities for osteosarcoma, the most common primary
cancer of bone, have changed very little over the past 30 years. The peak incidence of …

Osteosarcoma is the most common primary malignancy of bone in children and young
adults. This tumor has a very heterogeneous genetic profile and lacks any consistent …

Sarcomas account for over 20% of all pediatric solid malignant cancers and less than 1% of
all adult solid malignant cancers. The vast majority of diagnosed sarcomas will be soft tissue …

The 600% increase in medical radiation exposure to the US population since 1980 has
provided immense benefit, but increased potential future cancer risks to patients. Most of the …

Despite significant advancements in the diagnosis and treatment of osteosarcoma to date,
overall survival has remained relatively constant for over 2 decades. The challenge in …

Retinoblastoma (RB) is the most common intraocular malignancy in childhood.
Approximately 40% of retinoblastomas are hereditary and due to germline mutations in the …