[HTML][HTML] FOLFOX/FOLFIRI pharmacogenetics: the call for a personalized approach in colorectal cancer therapy
B Mohelnikova-Duchonova, B Melichar… - World journal of …, 2014 - ncbi.nlm.nih.gov
While 5-fluorouracil used as single agent in patients with metastatic colorectal cancer has an
objective response rate around 20%, the administration of combinations of irinotecan with 5 …
objective response rate around 20%, the administration of combinations of irinotecan with 5 …
Specificity protein 1: Its role in colorectal cancer progression and metastasis
R Bajpai, GP Nagaraju - Critical reviews in oncology/hematology, 2017 - Elsevier
Abstract Specificity protein 1 (Sp1) is a widely expressed transcription factor that plays an
important role in the promotion of oncogenes required for tumor survival, progression and …
important role in the promotion of oncogenes required for tumor survival, progression and …
Celastrol suppresses nitric oxide synthases and the angiogenesis pathway in colorectal cancer
The thunder god vine (Tripterygium wilfordii Hook. F) is traditionally used for inflammation-
related diseases in traditional Chinese medicine. In recent years, celastrol (a natural …
related diseases in traditional Chinese medicine. In recent years, celastrol (a natural …
Mitochondrial neurogastrointestinal encephalomyopathy caused by thymidine phosphorylase enzyme deficiency: from pathogenesis to emerging therapeutic options
R Yadak, P Sillevis Smitt… - Frontiers in cellular …, 2017 - frontiersin.org
Mitochondrial neurogastrointestinal encephalomyopathy (MNGIE) is a progressive
metabolic disorder caused by thymidine phosphorylase (TP) enzyme deficiency. The lack of …
metabolic disorder caused by thymidine phosphorylase (TP) enzyme deficiency. The lack of …
Syndecan-1, epithelial-mesenchymal transition markers (E-cadherin/β-catenin) and neoangiogenesis-related proteins (PCAM-1 and Endoglin) in colorectal cancer
The Syndecan-1 protein plays a crucial role in cell proliferation, cell adhesion, cell migration
and angiogenesis and, at the same time, its co-expression with E-cadherin is regulated …
and angiogenesis and, at the same time, its co-expression with E-cadherin is regulated …
Identification and role of differentially expressed genes/proteins between pulmonary tuberculosis patients and controls across lung tissues and blood samples
Q Li, K Maierheba - Immunity, Inflammation and Disease, 2024 - Wiley Online Library
Background Differentially expressed genes/proteins (DEGs/DEPs) play critical roles in
pulmonary tuberculosis (PTB) diagnosis and treatment. However, there is a scarcity of …
pulmonary tuberculosis (PTB) diagnosis and treatment. However, there is a scarcity of …
Pharmacogenetics of anticancer drug sensitivity and toxicity in colorectal cancer
R Moradi-Marjaneh, M Khazaei, S Seifi… - Current …, 2018 - ingentaconnect.com
Inter-individual differences in drug response are an important cause of failure in anticancer
treatment and adverse drug events in cancer patients. Gene polymorphisms related to these …
treatment and adverse drug events in cancer patients. Gene polymorphisms related to these …
Rs11479 in Thymidine Phosphorylase Associated with Prognosis of Patients with Colorectal Cancer Who Received Capecitabine-Based Adjuvant Chemotherapy
X Jia, T Zhang, J Sun, H Lin, T Bai, Y Qiao… - Pharmacogenomics …, 2023 - Taylor & Francis
Objective Thymidine Phosphorylase (TYMP) gene was of potential significance in the
process of colorectal cancer (CRC) development and played an important role in …
process of colorectal cancer (CRC) development and played an important role in …
Differential interference of vitamin D analogs PRI-1906, PRI-2191, and PRI-2205 with the renewal of human colon cancer cells refractory to treatment with 5 …
A Kotlarz, M Przybyszewska, P Swoboda… - Tumor Biology, 2016 - Springer
This study was aimed to determine whether hypocalcemic analogs of active forms of
vitamins D modulate expression of genes related to stem-like phenotype in colon cancer cell …
vitamins D modulate expression of genes related to stem-like phenotype in colon cancer cell …
Changes in thymidine phosphorylase gene expression related to treatment of rectal cancer
K Derwinger, EB Lindskog, E Palmqvist… - Anticancer …, 2013 - ar.iiarjournals.org
Background: The enzyme thymidine phosphorylase (TYMP) has tumor-promoting functions
and its expression is often elevated in tumors. Patients and Methods: TYMP gene …
and its expression is often elevated in tumors. Patients and Methods: TYMP gene …