Click chemistry approaches for developing carbonic anhydrase inhibitors and their applications
A Angeli, CT Supuran - Journal of Enzyme Inhibition and Medicinal …, 2023 - Taylor & Francis
Click chemistry reactions constitute an important and relatively new approach in the
medicinal chemistry toolbox and offer substantial advantages to medicinal chemists in terms …
medicinal chemistry toolbox and offer substantial advantages to medicinal chemists in terms …
Discovery of novel benzenesulfonamides incorporating 1, 2, 3-triazole scaffold as carbonic anhydrase I, II, IX, and XII inhibitors
Sulfonamides are among the most promising potential inhibitors for carbonic anhydrases
(CAs), which are pharmaceutically relevant targets for treating several disease conditions …
(CAs), which are pharmaceutically relevant targets for treating several disease conditions …
Design, synthesis, and biological activity of novel dithiocarbamate‐methylsulfonyl hybrids as carbonic anhydrase inhibitors
Carbonic anhydrase (CA) enzymes are involved in many physiological events. These
enzymes, which contain Zn2+ in their structure, can be easily inhibited by dithiocarbamate …
enzymes, which contain Zn2+ in their structure, can be easily inhibited by dithiocarbamate …
New bis-and tetrakis-1, 2, 3-triazole derivatives: Synthesis, DNA cleavage, molecular docking, antimicrobial, antioxidant activity and acid dissociation constants
In this study, a series of bis–and tetrakis–1, 2, 3–triazole derivatives were synthesized using
copper-catalyzed azide-alkyne cycloaddition (CuAAC) click chemistry in 73–95% yield. The …
copper-catalyzed azide-alkyne cycloaddition (CuAAC) click chemistry in 73–95% yield. The …
Discovery of novel drugs for Chagas disease: is carbonic anhydrase a target for antiprotozoal drugs?
A Beatriz Vermelho, GC Rodrigues… - Expert Opinion on …, 2022 - Taylor & Francis
Introduction Carbonic anhydrase (CA) arose significant interest as a potential new target for
Chagas disease since its discovery in Trypanosoma cruzi in 2013. Benznidazole and …
Chagas disease since its discovery in Trypanosoma cruzi in 2013. Benznidazole and …
Synthesis and anticancer activity of new benzensulfonamides incorporating s-triazines as cyclic linkers for inhibition of carbonic anhydrase IX
Limited presence of hCA IX in normal physiological tissues and their overexpression only in
solid hypoxic tumors made this isoform excellent possible target for developing new …
solid hypoxic tumors made this isoform excellent possible target for developing new …
Development of benzene and benzothiazole-sulfonamide analogues as selective inhibitors of the tumor-associated carbonic anhydrase IX
With an aim to develop novel potential antitumor agents, two series of benzene-and
benzothiazole-sulfonamide derivatives, acting as effective human carbonic anhydrase (hCA …
benzothiazole-sulfonamide derivatives, acting as effective human carbonic anhydrase (hCA …
Dual targeting of acetylcholinesterase and tau aggregation: Design, synthesis and evaluation of multifunctional deoxyvasicinone analogues for Alzheimer's disease
Abstract Development of multitargeted ligands have demonstrated remarkable efficiency as
potential therapeutics for Alzheimer's disease (AD). Herein, we reported a new series of …
potential therapeutics for Alzheimer's disease (AD). Herein, we reported a new series of …
Novel benzenesulfonamide derivatives as potential selective carbonic anhydrase IX, XII inhibitors with anti-proliferative activity: Design, synthesis and in silico studies
As inhibitors of carbonic anhydrases (CAs) IX and XII, a novel series of 1, 2, 3-triazole
benzenesulfonamide derivatives 17a-l containing pyrazolyl-thiazole moiety was designed …
benzenesulfonamide derivatives 17a-l containing pyrazolyl-thiazole moiety was designed …
Tail-approach based design and synthesis of Arylthiazolylhydrazono-1, 2, 3-triazoles incorporating sulfanilamide and metanilamide as human carbonic anhydrase I, II …
A library of twenty-two arylthiazolylhydrazono-1, 2, 3-triazoles incorporating sulfanilamide
and metanilamide moieties have been synthesized by utilizing tail-approach and …
and metanilamide moieties have been synthesized by utilizing tail-approach and …