Nox enzymes, ROS, and chronic disease: an example of antagonistic pleiotropy
JD Lambeth - Free Radical Biology and Medicine, 2007 - Elsevier
Reactive oxygen species (ROS) are considered to be chemically reactive with and
damaging to biomolecules including DNA, protein, and lipid, and excessive exposure to …
damaging to biomolecules including DNA, protein, and lipid, and excessive exposure to …
Kv3 channels: enablers of rapid firing, neurotransmitter release, and neuronal endurance
LK Kaczmarek, Y Zhang - Physiological reviews, 2017 - journals.physiology.org
The intrinsic electrical characteristics of different types of neurons are shaped by the K+
channels they express. From among the more than 70 different K+ channel genes …
channels they express. From among the more than 70 different K+ channel genes …
Role of TGFβ signaling in the pathogenesis of Alzheimer's disease
Aging is the main risk factor for Alzheimer's disease (AD); being associated with
conspicuous changes on microglia activation. Aged microglia exhibit an increased …
conspicuous changes on microglia activation. Aged microglia exhibit an increased …
Alzheimer's disease: redox dysregulation as a common denominator for diverse pathogenic mechanisms
R Von Bernhardi, J Eugenín - Antioxidants & redox signaling, 2012 - liebertpub.com
Alzheimer's disease (AD) is the most common cause of dementia and a progressive
neurodegeneration that appears to result from multiple pathogenic mechanisms (including …
neurodegeneration that appears to result from multiple pathogenic mechanisms (including …
l-Theanine, an amino acid in green tea, attenuates β-amyloid-induced cognitive dysfunction and neurotoxicity: reduction in oxidative damage and inactivation of ERK …
TI Kim, YK Lee, SG Park, IS Choi, JO Ban… - Free Radical Biology …, 2009 - Elsevier
Amyloid β (Aβ)-induced neurotoxicity is a major pathological mechanism of Alzheimer
disease (AD). In this study, we investigated the inhibitory effect of l-theanine, a component of …
disease (AD). In this study, we investigated the inhibitory effect of l-theanine, a component of …
NOX enzymes as novel targets for drug development
The members of the NOX/DUOX family of NADPH oxidases mediate such physiologic
functions as host defense, cell signaling, and thyroid hormone biosynthesis through the …
functions as host defense, cell signaling, and thyroid hormone biosynthesis through the …
Voltage-gated potassium channels at the crossroads of neuronal function, ischemic tolerance, and neurodegeneration
NH Shah, E Aizenman - Translational stroke research, 2014 - Springer
Voltage-gated potassium (Kv) channels are widely expressed in the central and peripheral
nervous system and are crucial mediators of neuronal excitability. Importantly, these …
nervous system and are crucial mediators of neuronal excitability. Importantly, these …
The Antioxidant Activity of Limonene Counteracts Neurotoxicity Triggered byAβ1-42 Oligomers in Primary Cortical Neurons
Many natural-derived compounds, including the essential oils from plants, are investigated
to find new potential protective agents in several neurodegenerative disorders such as …
to find new potential protective agents in several neurodegenerative disorders such as …
Curcumin a potent cancer preventive agent: Mechanisms of cancer cell killing
M Tuorkey - Interventional Medicine and Applied Science, 2014 - akjournals.com
There is no doubt that diet could effectively improve health and halt cancers. Dietary
phytochemical compounds and their derivatives represent a cornucopia of effectively …
phytochemical compounds and their derivatives represent a cornucopia of effectively …
Lavender and coriander essential oils and their main component linalool exert a protective effect against amyloid‐β neurotoxicity
L Caputo, I Piccialli, R Ciccone… - Phytotherapy …, 2021 - Wiley Online Library
Alzheimer's disease (AD) is a neurodegenerative disorder leading to cognitive deficits and
cognitive decline. Since no cure or preventing therapy is currently available to counteract …
cognitive decline. Since no cure or preventing therapy is currently available to counteract …