Major depressive disorder is a highly debilitating psychiatric disorder involving the
dysfunction of different cell types in the brain. Microglia are the predominant resident …

Over the past three decades, an intricate interaction between immune activation, release of
pro-inflammatory cytokines and changes in brain circuits related to mood and behavior has …

Chemokines are known to be immunoregulatory proteins involved not only in lymphocyte
chemotaxis to the site of inflammation, but also in neuromodulation, neurogenesis, and …

Maternal mental illness can have a devastating effect during the perinatal period, and has a
profound impact on the care that the baby receives and on the relationships that the baby …

The bidirectional communication between neurons and microglia is fundamental for the
proper functioning of the central nervous system (CNS). Chemokines and clusters of …

Prenatal alcohol exposure (PAE) can result in neurobehavioral anomalies, that may be
exacerbated by co-occurring metabolic and immune system deficits. To test the hypothesis …

Background The bidirectional communication between neurons and microglia is
fundamental for the homeostasis and biological function of the central nervous system …

Oligodendrocyte and neural precursor cells (OPCs and NPCs, respectively) in the central
nervous system (CNS) have diverse roles in development and homeostasis. During …

Neurological disorders occur in the central and peripheral nervous system and include
Alzheimer's disease, stroke, and spinal cord injury. Activation of the innate immune system …

Depression may be precipitated by the negative impact of chronic stress, which is
considered to play a key role in this neuropsychiatric disorder. Interestingly, depressed …