Adenosine receptors (ARs) are widely acknowledged pharmacological targets yet are still
underutilized in clinical practice. Their ubiquitous distribution in almost all cells and tissues …

Autism spectrum disorders (ASDs) are diagnosed in 1/100 children worldwide, based on two
core symptoms: deficits in social interaction and communication, and stereotyped …

JCI - Caffeine intake exerts dual genome-wide effects on hippocampal metabolism and
learning-dependent transcription Go to JCI Insight About Editors Consulting Editors For authors …

Major depressive disorder ranks as a major burden of disease worldwide, yet the current
antidepressant medications are limited by frequent non-responsiveness and significant side …

Cell lineage plasticity is one of the major causes for the failure of targeted therapies in
various cancers. However, the driver and actionable drug targets in promoting cancer cell …

Stroke is one of the leading causes of death and disability in the world, of which ischemia
accounts for the majority. There is growing evidence of changes in synaptic connections and …

The molecular code that controls synapse formation and maintenance in vivo has remained
quite sparse. Here, we identify that the secreted protein Adamtsl3 functions as critical …

Dysfunction of goal-directed behaviors under stressful or pathological conditions results in
impaired decision-making and loss of flexibility of thoughts and behaviors, which underlie …

Adenosine signals through four distinct G protein-coupled receptors that are located at
various synapses, cell types and brain areas. Through them, adenosine regulates …

The molecular mechanisms underlying circuit re-wiring in the mature brain remains ill-
defined. An eloquent example of adult circuit remodelling is the hippocampal mossy fiber …