Abstract Cyclin-dependent kinase 4 (CDK4) and CDK6 are critical mediators of cellular
transition into S phase and are important for the initiation, growth and survival of many …

Cyclins, cyclin-dependent kinases and other components of the core cell cycle machinery
drive cell division. Growing evidence indicates that this machinery operates in a distinct …

Totipotency is the ability of a single cell to give rise to all of the differentiated cell types that
build the conceptus, yet how to capture this property in vitro remains incompletely …

Since their characterization as conserved modules that regulate progression through the
eukaryotic cell cycle, cyclin-dependent protein kinases (CDKs) in higher eukaryotic cells are …

Proper progression throughout the cell division cycle depends on the expression level of a
family of proteins known as cyclins, and the subsequent activation of cyclin-dependent …

E-type cyclins, collectively called cyclin E, represent key components of the core cell cycle
machinery. In mammalian cells, two E-type cyclins, E1 and E2, activate cyclin-dependent …

The entry of mammalian cells into the DNA synthesis phase (S phase) represents a key
event in cell division. According to current models of the cell cycle, the kinase CDC7 …

Precise regulation of cellular proliferation is critical to tissue homeostasis and development,
but misregulation leads to diseases of excess proliferation or cell loss. To achieve precise …

Complete and robust human genome duplication requires loading minichromosome
maintenance (MCM) helicase complexes at many DNA replication origins, an essential …

Embryonic stem cells (ESCs) possess specific gene expression patterns that confer the
ability to proliferate indefinitely and enable pluripotency, which allows ESCs to differentiate …