Background Neuroinflammation has an important role in the pathophysiology of migraine,
which is a complex neuro-glio-vascular disorder. The main aim of this review is to highlight …

In the mid 1960s, experimental work on molecules under screening as coronary dilators
allowed the discovery of the mechanism of calcium entry blockade by drugs later named …

Background Blau theorized that migraine triggers are exposures that in higher amounts
would damage the brain. The recent discovery that the TRPA1 ion channel transduces …

Laser Speckle Contrast Imaging (LSCI) is a wide field of view, non scanning optical
technique for observing blood flow. Speckles are produced when coherent light scattered …

Mast cells are critical players in allergic reactions, but they have also been shown to be
important in immunity and recently also in inflammatory diseases, especially asthma …

Currently, migraine is treated mainly by targeting calcitonin gene-related peptides, although
the efficacy of this method is limited and new treatment strategies are desired …

Neuropeptide Y (NPY) is an abundant neuropeptide of the neocortex involved in numerous
physiological and pathological processes. Because of the large electrophysiological …

The pathogenesis of migraine is incompletely understood. Recent discoveries have shed
light on the neuronal events mediating both the aura and the headache phases of migraine …

Spreading depression (SD) is a slowly propagating wave of near-complete depolarization of
neurons and glial cells across the cortex. SD is thought to contribute to the underlying …

So far, no coherent and convincing theory has been developed to fully explain the
pathogenesis of migraine, although many researchers and experts emphasize its …