The endothelium plays important roles in modulating vascular tone by synthesizing and
releasing a variety of endothelium-derived relaxing factors, including vasodilator …

Cardiovascular and metabolic diseases (CVMD) are the leading causes of death worldwide,
underscoring the urgent necessity to develop new pharmacotherapies. Berberine (BBR) is …

Many local and systemic diseases especially diseases that are leading causes of death
globally like chronic obstructive pulmonary disease, atherosclerosis with ischemic heart …

Statins represent the cornerstone of pharmacotherapy for the prevention of atherosclerotic
cardiovascular disease. These medications not only reduce low-density lipoprotein …

Quercitrin is a naturally available type of flavonoid that commonly functions as the dietary
ingredient and supplement. So far, a wide spectrum of bioactivities of quercitrin have been …

e160 Arterioscler Thromb Vasc Biol September 2018 were actively exported to the
cytoplasm with exportin-5 in a Ran-GTP–dependent manner. In the cytoplasm, the transition …

Prussian Blue Nanozymes (PBNZs) have emerged as highly efficient agents for reactive
oxygen species (ROS) elimination, owing to their multiple enzyme-like properties …

Persistent inflammation within atherosclerotic plaques is a crucial factor contributing to
plaque vulnerability and rupture. It has become increasingly evident that the …

Curcumin, a primary active element of turmeric, has potent antioxidant and anti-inflammatory
activity, but its low bioavailability is a major hurdle in its pharmaceutical applications. To …

Background Exposure to ambient fine particulate matter (PM 2.5, with aerodynamic diameter
less than 2.5 µm) is a leading environmental risk factor for global cardiovascular health …