Neddylation, a post-translational modification that conjugates an ubiquitin-like protein
NEDD8 to substrate proteins, is an important biochemical process that regulates protein …

Post-translational modifications of cellular substrates with ubiquitin and ubiquitin-like
proteins (UBLs), including ubiquitin, SUMOs, and neural precursor cell–expressed …

Abstract Pevonedistat (TAK-924/MLN4924) is a novel inhibitor of NEDD8-activating enzyme
(NAE) with single-agent activity in relapsed/refractory acute myeloid leukemia (AML). We …

Cervical cancer is currently one of the major threats to women's health. The overexpression
of heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1) as the biomarker has …

Neddylation is a posttranslational modification that conjugates a ubiquitin-like protein
NEDD8 to substrate proteins. The best-characterized substrates of neddylation are the cullin …

There is no effective therapy for the lately increased incidence of glioblastoma multiforme
(GBM)—the most common primary brain tumor characterized by a high degree of …

Protein neddylation is a post-translational modification, and its best recognized substrates
are cullin family proteins, which are the core component of Cullin-RING ligases (CRLs) …

Inhibiting the protein neddylation pathway using the NEDD8‑activating enzyme inhibitor
MLN4924 represents an attractive anticancer strategy having been demonstrated to exhibit …

Increased neddylation benefits the survival of several types of cancer cells. The inhibition of
neddylation has the potential to exert anticancer effects but is rarely assessed in oral cancer …

NEDD8 (Neural precursor cell expressed developmentally downregulated protein 8) is an
ubiquitin-like protein that is covalently attached to a lysine residue of a protein substrate …