Morinda officinalis How.–A comprehensive review of traditional uses, phytochemistry and pharmacology

J Zhang, H Xin, Y Xu, Y Shen, YQ He, B Lin… - Journal of …, 2018 - Elsevier
Ethnopharmacological relevance The medicinal plant Morinda officinalis How.(MO) and its
root have long been used in traditional medicines in China and northeast Asia as tonics for …

[HTML][HTML] Therapeutic anabolic and anticatabolic benefits of natural Chinese medicines for the treatment of osteoporosis

J He, X Li, Z Wang, S Bennett, K Chen, Z Xiao… - Frontiers in …, 2019 - frontiersin.org
Osteoporosis is a bone disease characterized by increasing osseous fragility and fracture
due to the reduced bone mass and microstructural degradation. Primary pharmacological …

[HTML][HTML] Effect of Bifidobacterium on osteoclasts: TNF-α/NF-κB inflammatory signal pathway-mediated mechanism

Y Wu, Y Yang, L Wang, Y Chen, X Han, L Sun… - Frontiers in …, 2023 - frontiersin.org
Osteoporosis is a systemic multifactorial bone disease characterized by low bone quality
and density and bone microstructure damage, increasing bone fragility and fracture …

[HTML][HTML] Anti-inflammatory and antioxidant traditional Chinese Medicine in treatment and prevention of osteoporosis

Q Li, C Tian, X Liu, D Li, H Liu - Frontiers in Pharmacology, 2023 - frontiersin.org
A metabolic bone disorder called osteoporosis is characterized by decreased bone mass
and compromised microarchitecture. This condition can deteriorate bones and raise the risk …

[HTML][HTML] The RANKL-RANK axis: A bone to thymus round trip

C Sobacchi, C Menale, A Villa - Frontiers in immunology, 2019 - frontiersin.org
The identification of Receptor activator of nuclear factor kappa B ligand (RANKL) and its
cognate receptor Receptor activator of nuclear factor kappa B (RANK) during a search for …

Analysis of molecular mechanism of erxian decoction in treating osteoporosis based on formula optimization model

L Yang, L Fan, K Wang, Y Chen, L Liang… - Oxidative medicine …, 2021 - Wiley Online Library
Osteoporosis (OP) is a highly prevalent orthopedic condition in postmenopausal women and
the elderly. Currently, OP treatments mainly include bisphosphonates, receptor activator of …

Morinda officinalis polysaccharide enable suppression of osteoclastic differentiation by exosomes derived from rat mesenchymal stem cells

P Wu, F Jiao, H Huang, D Liu, W Tang… - Pharmaceutical …, 2022 - Taylor & Francis
Abstract Context Morinda officinalis FC How.(MO)(Rubiaceae) can strengthen bone function.
Objective To examine the functional mechanism and effect of MO polysaccharides (MOPs) in …

[HTML][HTML] Different roles of matrix metalloproteinase 2 in osteolysis of skeletal dysplasia and bone metastasis

X Li, L Jin, Y Tan - Molecular Medicine Reports, 2021 - spandidos-publications.com
Abstract Matrix metalloproteinase 2 (MMP2) is a well‑characterized protein that is
indispensable for extracellular matrix remodeling and other pathological processes, such as …

Bioassay-guided isolation and evaluation of anti-osteoporotic polysaccharides from Morinda officinalis

D Zhang, S Zhang, K Jiang, T Li, C Yan - Journal of Ethnopharmacology, 2020 - Elsevier
Ethnopharmacological relevance Morinda officinalis is a well-known Chinese tonic herb that
has shown clinical efficacy in the treatment of bone disease. However, its anti-osteoporotic …

Isolation, phytochemistry, characterization, biological activity, and application of Morinda officinalis How oligosaccharide: a review

J Yue, W Xia, Y Wang, Y Zhang, Y Zhang… - Journal of Pharmacy …, 2024 - academic.oup.com
Morinda officinalis How oligosaccharide (MOO) stands as one of the principal active
constituents of M. officinalis How, widely employed in traditional Chinese medicine. The …