The ANGPTL3-4-8 model, a molecular mechanism for triglyceride trafficking
R Zhang - Open biology, 2016 - royalsocietypublishing.org
Lipoprotein lipase (LPL) is a rate-limiting enzyme for hydrolysing circulating triglycerides
(TG) into free fatty acids that are taken up by peripheral tissues. Postprandial LPL activity …
(TG) into free fatty acids that are taken up by peripheral tissues. Postprandial LPL activity …
ANGPTL8: an important regulator in metabolic disorders
M Luo, D Peng - Frontiers in endocrinology, 2018 - frontiersin.org
Long-term controversy regarding the role of angiopoietin-like protein 8 (ANGPTL8) in beta-
cell proliferation and diabetes progression made it a research spotlight. Recently, the …
cell proliferation and diabetes progression made it a research spotlight. Recently, the …
ANGPTL8 in metabolic homeostasis: more friend than foe?
C Guo, C Wang, X Deng, J He, L Yang… - Open …, 2021 - royalsocietypublishing.org
ANGPTL8 is an important cytokine, which is significantly increased in type 2 diabetes
mellitus (T2DM), obesity and metabolic syndrome. Many studies have shown that ANGPTL8 …
mellitus (T2DM), obesity and metabolic syndrome. Many studies have shown that ANGPTL8 …
Increased levels of circulating IGFBP4 and ANGPTL8 with a prospective role in diabetic nephropathy
HT AlMajed, M Abu-Farha, E Alshawaf… - International Journal of …, 2023 - mdpi.com
Diabetic nephropathy (DN) is a complicated condition related to type 2 diabetes mellitus
(T2D). ANGPTL8 is a hepatic protein highlighted as a risk factor for DN in patients with T2D; …
(T2D). ANGPTL8 is a hepatic protein highlighted as a risk factor for DN in patients with T2D; …
Altered concentrations in dyslipidemia evidence a role for ANGPTL8/betatrophin in lipid metabolism in humans
J Gómez-Ambrosi, E Pascual-Corrales… - The Journal of …, 2016 - academic.oup.com
Context: Angiopoietin-like protein 8 (ANGPTL8)/betatrophin is a secreted protein initially
involved in β-cell replication. Recent data in humans and mice models suggest that …
involved in β-cell replication. Recent data in humans and mice models suggest that …
The impact of psoriasis and metabolic syndrome on the systemic inflammation and oxidative damage to nucleic acids
D Holmannova, L Borska, C Andrys… - Journal of …, 2020 - Wiley Online Library
Background. Psoriasis is a chronic systemic inflammatory disease associated with a wide
range of comorbidities, including metabolic syndrome (MetS). Serum calprotectin …
range of comorbidities, including metabolic syndrome (MetS). Serum calprotectin …
Emerging insights into the roles of ANGPTL8 beyond glucose and lipid metabolism
H Ye, Q Zong, H Zou, R Zhang - Frontiers in Physiology, 2023 - frontiersin.org
Angiopoietin-like protein 8 (ANGPTL8) is a secreted protein predominantly expressed in
liver and adipose tissue. ANGPTL8 modulates the clearance of triglycerides (TGs) by …
liver and adipose tissue. ANGPTL8 modulates the clearance of triglycerides (TGs) by …
Betatrophin and insulin resistance
Q Guo, S Cao, X Wang - Metabolites, 2022 - mdpi.com
Betatrophin (angiopoietin-like protein 8 (ANGPTL8)) is a hormone that was recently
discovered in the human liver. Multiple homologous sequences have been detected in …
discovered in the human liver. Multiple homologous sequences have been detected in …
Vitamin D modifies the associations between circulating betatrophin and cardiometabolic risk factors among youths at risk for metabolic syndrome
Background Betatrophin has been recently reported to play a role in glucose homeostasis
by inducing beta-cell proliferation in mice. However, studies in human are inconsistent. As a …
by inducing beta-cell proliferation in mice. However, studies in human are inconsistent. As a …
Triglyceride-mediated influence of serum angiopoietin-like protein 8 on subclinical atherosclerosis in type 2 diabetic patients: results from the GDMD study in China
T Zheng, B Ge, H Liu, B Chen, L Qin, L Xiao… - Cardiovascular …, 2018 - Springer
Background Hypertriglyceridemia, insulin resistance and hyperglycemia are risk factors for
atherosclerosis in type 2 diabetes. Angiopoietin-like protein 8 (ANGPTL8) is a newly …
atherosclerosis in type 2 diabetes. Angiopoietin-like protein 8 (ANGPTL8) is a newly …