Decades of research has recognized a solid role for Pim kinases in lymphoproliferative
disorders. Often up-regulated following JAK/STAT and tyrosine kinase receptor signaling …

Pim oncogenes are overexpressed in a wide range of tumours from a haematological and
epithelial origin. Pim genes encode serine/threonine kinases that have been shown to …

Genomic instability promotes tumorigenesis and can occur through various mechanisms,
including defective segregation of chromosomes or inactivation of DNA mismatch repair …

The identification as cooperating targets of Proviral Integrations of Moloney virus in murine
lymphomas suggested early on that PIM serine/threonine kinases play an important role in …

One of the greatest examples of integrated signal transduction is revealed by examination of
effects mediated by AKT kinase in myocardial biology. Positioned at the intersection of …

Pim-1 kinase is a member of a distinct class of serine/threonine kinases consisting of Pim-1,
Pim-2, and Pim-3. Pim kinases are highly homologous to one another and share a unique …

Pim-1 belongs to a family of serine/threonine protein kinases that are highly conserved
through evolution in multicellular organisms. Originally identified from Moloney murine …

Pim kinases are found to be highly expressed in leukemia, lymphoma, prostate and
pancreatic cancer. Bitransgenic mice overexpressing either Pim-1 or Pim-2 and c-Myc …

The pim-1 oncogene is regulated by hematopoietic cytokine receptors, encodes a
serine/threonine protein kinase, and cooperates with c-myc in lymphoid cell transformation …

The pim-1 oncogene encodes a serine/threonine kinase (Pim-1) involved in the transduction
of cytokine-triggered mitogenic signals. Pim-1 is unique in that it closely cooperates with c …