Role of natural and synthetic compounds in modulating NRF2/KEAP1 signaling pathway in prostate cancer

G Tossetta, S Fantone, D Marzioni, R Mazzucchelli - Cancers, 2023 - mdpi.com
Simple Summary Several studies showed that oxidative stress is involved in cancer
occurrence, development, progression chemoresistance and radio resistance. The nuclear …

Helichrysum italicum: From Extraction, Distillation, and Encapsulation Techniques to Beneficial Health Effects

V Furlan, U Bren - Foods, 2023 - mdpi.com
Helichrysum italicum (family Asteraceae), due to its various beneficial health effects,
represents an important plant in the traditional medicine of Mediterranean countries …

Antioxidant, alpha-glucosidase inhibition activities, in silico molecular docking and pharmacokinetics study of phenolic compounds from native australian fruits and …

A Ali, JJ Cottrell, FR Dunshea - Antioxidants, 2023 - mdpi.com
Native Australian fruits and spices are enriched with beneficial phytochemicals, especially
phenolic compounds, which are not fully elucidated. Therefore, this study aimed to analyze …

Chemical composition, functional and anticancer properties of carrot

L Mandrich, AV Esposito, S Costa, E Caputo - Molecules, 2023 - mdpi.com
Plants are a valuable source of drugs for cancer treatment. Daucus carota has been
investigated for its health properties. In particular, Daucus carota L. subsp. Sativus, the …

Overexpression of glutathione S-transferases in human diseases: Drug targets and therapeutic implications

N Lv, C Huang, H Huang, Z Dong, X Chen, C Lu… - Antioxidants, 2023 - mdpi.com
Glutathione S-transferases (GSTs) are a major class of phase II metabolic enzymes. Besides
their essential role in detoxification, GSTs also exert diverse biological activities in the …

Multiple Bioactivities of Peptides from Hydrolyzed Misgurnus anguillicaudatus

B Dou, X Wu, Z Xia, G Wu, Q Guo, M Lyu, S Wang - Molecules, 2023 - mdpi.com
Misgurnus anguillicaudatus (loach) is a widely distributed benthic fish in Asia. In this study,
the alkaline protease was used to hydrolyze loach, and the hydrolysate products of different …

Novel coumarin-6-sulfonamide-chalcone hybrids as glutathione transferase P1-1 inhibitors

A Sabt, S Kitsos, MS Ebaid, V Furlan, PD Pantiora… - Plos one, 2024 - journals.plos.org
Multidrug resistance (MDR) mechanisms in cancer cells are greatly influenced by
glutathione transferase P1-1 (hGSTP1-1). The use of synthetic or natural compounds as …

Computational-Simulation-Based Behavioral Analysis of Chemical Compounds

P Rajendran, R Rathinasabapathy… - Journal of Composites …, 2023 - mdpi.com
This research focuses on obtaining the behavior of chemical compounds with respect to
their molecular weight and optimization energy based on the variation in properties in …

BRCA1/TP53 tumor proteins inhibited by novel analogues of curcumin—Insight from computational modelling, dynamic simulation and experimental validation

LJ Aloor, S Skariyachan, AC Raghavamenon… - International Journal of …, 2023 - Elsevier
The current study aimed to design novel curcumin analogue inhibitors with antiproliferative
and antitumor activity towards BRCA1 and TP53 tumor proteins and to study their …

Inhibition Analysis and High-Resolution Crystal Structure of Mus musculus Glutathione Transferase P1-1

O Kupreienko, F Pouliou, K Konstandinidis, I Axarli… - Biomolecules, 2023 - mdpi.com
Multidrug resistance is a significant barrier that makes anticancer therapies less effective.
Glutathione transferases (GSTs) are involved in multidrug resistance mechanisms and play …