Introduction This review summarizes our current understanding of the respiratory
microbiome in COPD and Bronchiectasis. We explore the interplay between microbial …

Cystic fibrosis (CF) is an autosomal recessive multisystem disorder caused by mutations in
the cystic fibrosis conductance regulator (CFTR) anion channel. In the lungs specifically …

Background Progression of chronic lung disease may lead to the requirement for lung
transplant (LTx). Despite improvements in short-term survival after LTx, chronic lung allograft …

Dysfunction of the cystic fibrosis transmembrane conductance regulator (CFTR) anion
channel by genetic mutations causes the inherited disease cystic fibrosis (CF). CF lung …

Background: A significant decline in pulmonary exacerbation rates has been reported in CF
patients homozygous for F508del treated with lumacaftor/ivacaftor. However, it is still unclear …

Background Oral health impacts systemic health, individual well-being, and quality of life. It
is important to identify conditions that may exacerbate oral disease to aid public health and …

Burkholderia cepacia complex infections remain life-threatening to cystic fibrosis patients,
and due to the limited eradication efficiency of current treatments, novel antimicrobial …

Background Triple modulator therapy elexacaftor/tezacaftor/ivacaftor (ETI) improves lung
function and impacts upon the respiratory microbiome in people with Cystic fibrosis (pwCF) …

Most in vitro models lack the capacity to fully probe bacterial phenotypes emerging from the
complex interactions observed in real-life environments. This is particularly true in the …

Cystic Fibrosis (CF) is an autosomal recessive disorder caused by mutations to the Cystic
Fibrosis Transmembrane-conductance Regulator (CFTR) gene, that leads to the buildup of …