The transforming growth factor-β (TGFβ) family are a large group of evolutionarily conserved
cytokines whose signalling modulates cell fate decision-making across varying cellular …

Heart disease is the leading cause of death worldwide. Despite decades of research, most
heart pathologies have limited treatments, and often the only curative approach is heart …

Transforming growth factor-beta (TGFβ) is released from cells as part of a trimeric latent
complex consisting of TGFβ, the TGFβ propeptides, and either a latent TGFβ binding protein …

Thoracic aortic aneurysm (TAA) has a prevalence of 0.16–0.34% and an incidence of 7.6
per 100,000 person-years, accounting for 1–2% of all deaths in Western countries …

Zebrafish have a remarkable ability to regenerate injured hearts. Altered hemodynamic
forces after larval ventricle ablation activate the endocardial Klf2a-Notch signaling cascade …

Aortic aneurysm is a vascular disease characterized by irreversible vasodilatation that can
lead to dissection and rupture of the aortic aneurysm, a life-threatening condition. Thoracic …

BACKGROUND: Abdominal aortic aneurysm (AAA) is characterized by weakening and
dilatation of the aortic wall in the abdomen. The aim of this study was to gain insight into cell …

Objective: The zebrafish is increasingly used as a small animal model for cardiovascular
disease, including vascular disorders. Nevertheless, a comprehensive biomechanical …

Zebrafish are increasingly becoming an important model organism for studying the
pathophysiological mechanisms of human diseases and investigating how these …

Aortic aneurysm/dissection (AAD) poses a life-threatening cardiovascular emergency with
complex mechanisms and a notably high mortality rate. Zebrafish (Danio rerio) serve as …