Skeletal muscle hypertrophy can be induced by hormones and growth factors acting directly
as positive regulators of muscle growth or indirectly by neutralizing negative regulators, and …

Changes in gene expression in the brain may underlie cognitive deficits inherent to normal
aging and neurodegenerative disease. However, the mechanisms underlying pathological …

The acetylation and deacetylation of histones plays an important role in the regulation of
gene transcriptions. Histone acetylation is mediated by histone acetyltransferase; the …

Oxidative stress has been implicated in the etiology of age-related muscle loss (sarcopenia).
However, the underlying mechanisms by which oxidative stress contributes to sarcopenia …

Amyotrophic lateral sclerosis (ALS) is a fatal adult‐onset disease primarily characterized by
upper and lower motor neuron degeneration, muscle wasting and paralysis. It is increasingly …

MicroRNAs are small non-coding RNAs that participate in different biological processes,
providing subtle combinational regulation of cellular pathways, often by regulating …

Inhibition of class IIa histone deacetylase (HDAC) enzymes have been suggested as a
therapeutic strategy for a number of diseases, including Huntington's disease. Catalytic-site …

Most human phenotypes are influenced by a combination of genomic and environmental
factors. Engaging in regular physical exercise prevents many chronic diseases, decreases …

Amyotrophic lateral sclerosis is a typically rapidly progressive neurodegenerative disorder
affecting motor neurons leading to progressive muscle paralysis and death, usually from …

Regular physical activity positively influences whole body energy metabolism and substrate
handling in exercising muscle. While it is recognized that the effects of exercise extend …