Structural analysis and biological effects of a neutral polysaccharide from the fruits of Rosa laevigata

J Zhang, Z Song, Y Li, S Zhang, J Bao, H Wang… - Carbohydrate …, 2021 - Elsevier
A neutral water-soluble polysaccharide (RLP50-2) was extracted and purified from the fruits
of Rosa laevigata. The absolute molecular weight was determined as 1.26× 10 4 g/mol …

Endothelial loss of ETS1 impairs coronary vascular development and leads to ventricular non-compaction

L Wang, L Lin, H Qi, J Chen, P Grossfeld - Circulation research, 2022 - Am Heart Assoc
Rationale: Jacobsen syndrome is a rare chromosomal disorder caused by deletions in the
long arm of human chromosome 11, resulting in multiple developmental defects including …

Stiff extracellular matrix drives the differentiation of mesenchymal stem cells toward osteogenesis by the multiscale 3D genome reorganization

J Na, C Tai, Z Wang, Z Yang, X Chen, J Zhang… - Biomaterials, 2025 - Elsevier
Extracellular matrix (ECM) stiffness is a major driver of stem cell fate. However, the
involvement of the three-dimensional (3D) genomic reorganization in response to ECM …

Assessing the effects of aging on the renal endothelial cell landscape using single-cell RNA sequencing

M Li, D Wang, Z Liu, Y Huang, Q Zhang, C Pan… - Frontiers in …, 2023 - frontiersin.org
Endothelial cells (ECs) with senescence-associated secretory phenotypes (SASP) have
been identified as a key mechanism of aging that contributes to various age-related kidney …

The transcription factor Ets1 influences axonal growth via regulation of Lcn2

M Gu, X Li, R Wu, X Cheng, S Zhou, X Gu - Molecular Neurobiology, 2024 - Springer
Transcription factors are essential for the development and regeneration of the nervous
system. The current study investigated key regulatory transcription factors in rat spinal cord …

ETS1, a Target Gene of the EWSR1::FLI1 Fusion Oncoprotein, Regulates the Expression of the Focal Adhesion Protein TENSIN3

VJ Ebegboni, TL Jones, T Brownmiller, PX Zhao… - Molecular Cancer …, 2024 - AACR
The mechanistic basis for the metastasis of Ewing sarcomas remains poorly understood, as
these tumors harbor few mutations beyond the chromosomal translocation that initiates the …

LncRNA MALAT1 knockdown inhibits the development of choroidal neovascularization

X Zhang, S Du, D Yang, X Jin, Y Zhang, D Wang… - Heliyon, 2023 - cell.com
In the pathogenesis of age-related macular degeneration, long non-coding RNAs have
become important regulators. This study aimed to investigate the role of metastasis …

[HTML][HTML] Endocardium gives rise to blood cells in zebrafish embryos

S Gurung, NK Restrepo, S Sumanas - Cell reports, 2024 - cell.com
Previous studies have suggested that the endocardium contributes to hematopoiesis in
murine embryos, although definitive evidence to demonstrate the hematopoietic potential of …

Spiromesifen contributes vascular developmental toxicity via disrupting endothelial cell proliferation and migration in zebrafish embryos

M Wang, J Liu, H Wang, T Hu - Pesticide Biochemistry and Physiology, 2022 - Elsevier
Spiromesifen (SPF) is a specific contact pesticide, which has been widely used to control the
growth of sucking insects like mites and whiteflies on crops. Although its residues in crops …

Single-Cell RNA Sequencing of Sox17-Expressing Lineages Reveals Distinct Gene Regulatory Networks and Dynamic Developmental Trajectories

LT Trinh, AB Osipovich, B Liu, S Shrestha… - Stem …, 2023 - academic.oup.com
During early embryogenesis, the transcription factor SOX17 contributes to hepato-pancreato-
biliary system formation and vascular-hematopoietic emergence. To better understand …