As the home of cellular genetic information, the nucleus has a critical role in determining cell
fate and function in response to various signals and stimuli. In addition to biochemical …

Cells and tissues generate and are exposed to various mechanical forces that act across a
range of scales, from tissues to cells to organelles. Forces provide crucial signals to inform …

In metazoan cell nuclei, hundreds of large chromatin domains are in close contact with the
nuclear lamina. Such lamina-associated domains (LADs) are thought to help organize …

It is well established that cells sense chemical signals from their local microenvironment and
transduce them to the nucleus to regulate gene expression programmes. Although a number …

At the nuclear periphery, associations of chromatin with the nuclear lamina through lamina-
associated domains (LADs) aid functional organization of the genome. We review the …

Nuclear chromosomes transcribe far more RNA than required to encode protein. Here we
investigate whether non-coding RNA broadly contributes to cytological-scale chromosome …

Products of the LMNA gene, primarily lamin A and C, are key components of the nuclear
lamina, a proteinaceous meshwork that underlies the inner nuclear membrane and is …

Premature aging disorders provide an opportunity to study the mechanisms that drive aging.
In Hutchinson-Gilford progeria syndrome (HGPS), a mutant form of the nuclear scaffold …

The genome is packaged and organized nonrandomly within the 3D space of the nucleus to
promote efficient gene expression and to faithfully maintain silencing of heterochromatin …

Chromatin has distinct three-dimensional (3D) architectures important in key biological
processes, such as cell cycle, replication, differentiation, and transcription regulation. In turn …