Ageing and rejuvenation of tissue stem cells and their niches
Most adult organs contain regenerative stem cells, often organized in specific niches. Stem
cell function is critical for tissue homeostasis and repair upon injury, and it is dependent on …
cell function is critical for tissue homeostasis and repair upon injury, and it is dependent on …
The key roles of the lysine acetyltransferases KAT6A and KAT6B in physiology and pathology
N Wiesel-Motiuk, YG Assaraf - Drug Resistance Updates, 2020 - Elsevier
Histone modifications and more specifically ε-lysine acylations are key epigenetic regulators
that control chromatin structure and gene transcription, thereby impacting on various …
that control chromatin structure and gene transcription, thereby impacting on various …
[HTML][HTML] Hematopoietic Stem Cells and the Immune System in Development and Aging
D Shevyrev, V Tereshchenko, TN Berezina… - International Journal of …, 2023 - mdpi.com
Hematopoietic stem cells (HSCs) support haematopoiesis throughout life and give rise to the
whole variety of cells of the immune system. Developing in the early embryo, passing …
whole variety of cells of the immune system. Developing in the early embryo, passing …
An aged bone marrow niche restrains rejuvenated hematopoietic stem cells
N Guidi, G Marka, V Sakk, Y Zheng, MC Florian… - Stem Cells, 2021 - academic.oup.com
Aging-associated leukemia and aging-associated immune remodeling are in part caused by
aging of hematopoietic stem cells (HSCs). An increase in the activity of the small …
aging of hematopoietic stem cells (HSCs). An increase in the activity of the small …
Functional genomics of inflamm-aging and immunosenescence
RJ Lu, EK Wang, BA Benayoun - Briefings in functional …, 2022 - academic.oup.com
The aging population is at a higher risk for age-related diseases and infections. This
observation could be due to immunosenescence: the decline in immune efficacy of both the …
observation could be due to immunosenescence: the decline in immune efficacy of both the …
Histone acetyltransferases and stem cell identity
R He, A Dantas, K Riabowol - Cancers, 2021 - mdpi.com
Simple Summary Gene regulation is the major mechanism that allows us to develop from a
single cell to a fully formed adult body containing numerous organs and tissues,> 200 cell …
single cell to a fully formed adult body containing numerous organs and tissues,> 200 cell …
[HTML][HTML] Human hematopoiesis: aging and leukemogenic risk
ER Adelman, ME Figueroa - Current opinion in hematology, 2021 - ncbi.nlm.nih.gov
Human hematopoiesis: aging and leukemogenic risk - PMC Back to Top Skip to main
content NIH NLM Logo Access keys NCBI Homepage MyNCBI Homepage Main Content …
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[HTML][HTML] Epigenetic Profiling of PTPN11 Mutant JMML Hematopoietic Stem and Progenitor Cells Reveals an Aberrant Histone Landscape
R Sinha, M Dvorak, A Ganesan, L Kalesinskas… - Cancers, 2023 - mdpi.com
Simple Summary Juvenile myelomonocytic leukemia (JMML) is a deadly pediatric leukemia
with limited treatment options and poor clinical outcomes. Effective targeted treatment …
with limited treatment options and poor clinical outcomes. Effective targeted treatment …
The role of the stem cell epigenome in normal aging and rejuvenative therapy
J Jayarajan, MD Milsom - Human molecular genetics, 2020 - academic.oup.com
Adult stem cells are ultimately responsible for the lifelong maintenance of regenerating of
tissues during both homeostasis and following injury. Hence, the functional attrition of adult …
tissues during both homeostasis and following injury. Hence, the functional attrition of adult …
[HTML][HTML] Regulation of Stress Induced Hematopoiesis
GA Anderson, M Rodriguez… - Current opinion in …, 2020 - ncbi.nlm.nih.gov
Regulation of Stress Induced Hematopoiesis - PMC Back to Top Skip to main content NIH NLM
Logo Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation …
Logo Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation …