Most adult organs contain regenerative stem cells, often organized in specific niches. Stem
cell function is critical for tissue homeostasis and repair upon injury, and it is dependent on …

Histone modifications and more specifically ε-lysine acylations are key epigenetic regulators
that control chromatin structure and gene transcription, thereby impacting on various …

Hematopoietic stem cells (HSCs) support haematopoiesis throughout life and give rise to the
whole variety of cells of the immune system. Developing in the early embryo, passing …

Hematopoietic stem cells (HSCs) are essential for maintaining overall health by
continuously generating blood cells throughout an individual's lifespan. However, as …

The aging population is at a higher risk for age-related diseases and infections. This
observation could be due to immunosenescence: the decline in immune efficacy of both the …

Human hematopoiesis: aging and leukemogenic risk : Current Opinion in Hematology Human
hematopoiesis: aging and leukemogenic risk : Current Opinion in Hematology Log in or …

Simple Summary Gene regulation is the major mechanism that allows us to develop from a
single cell to a fully formed adult body containing numerous organs and tissues,> 200 cell …

Aging-associated leukemia and aging-associated immune remodeling are in part caused by
aging of hematopoietic stem cells (HSCs). An increase in the activity of the small …

Human adipose-derived stem cells (ASCs) have shown immense potential for regenerative
medicine. Our previous work demonstrated that chitosan nano-deposited surfaces induce …

The histone lysine acetyltransferase KAT6B (MYST4, MORF, QKF) is the target of recurrent
chromosomal translocations causing hematological malignancies with poor prognosis …