The NOTCH gene was identified approximately 110 years ago. Classical studies have
revealed that NOTCH signaling is an evolutionarily conserved pathway. NOTCH receptors …

Notch signaling is an evolutionarily highly conserved signaling mechanism, but in contrast to
signaling pathways such as Wnt, Sonic Hedgehog, and BMP/TGF-β, Notch signaling occurs …

Regulated mechanisms of stem cell maintenance are key to preventing stem cell depletion
and aging. While mitochondrial morphology plays a fundamental role in tissue development …

During vertebrate development, a wide variety of cell types and tissues emerge from a single
fertilized oocyte. One of these tissues, the central nervous system, contains many types of …

Using an unbiased systems genetics approach, we previously predicted a role for CHAC1 in
the endoplasmic reticulum stress pathway, linked functionally to activating transcription …

Notch signaling is evolutionarily conserved from Drosophila to human. It plays critical roles
in neural stem cell maintenance and neurogenesis in the embryonic brain as well as in the …

Peptides, short protein fragments, can emulate the functions of their full-length native
counterparts. Peptides are considered potent recombinant protein alternatives due to their …

Background Activated microglia-mediated neuroinflammation has been regarded as an
underlying key player in the pathogenesis of subarachnoid hemorrhage (SAH)-induced …

Significance: Glutathione degradation has for long been thought to occur only on
noncytosolic pools. This is because there has been only one enzyme known to degrade …

Glioblastoma multiforms (GBMs) are highly vascularized brain tumors containing a
subpopulation of multipotent cancer stem cells. These cells closely interact with endothelial …