Aromatic amines and heterocyclic aromatic amines (HAAs) are structurally related classes of
carcinogens that are formed during the combustion of tobacco or during the high …

Considerable support exists for the roles of metabolism in modulating the carcinogenic
properties of chemicals. In particular, many of these compounds are pro-carcinogens that …

The cytochrome P450 proteins (CYPs) are a family of haem proteins resulting from
expression of a gene super-family that currently contains around 1000 members in species …

Heterocyclic amines (HAs) occur at the ppb range in foods. Most of them demonstrate potent
mutagenicity in bacteria mutagenicity test, and some of them have been classified by the …

Heterocyclic aromatic amines (HAAs) form during the high-temperature cooking of meats,
poultry, and fish. Some HAAs also arise during the combustion of tobacco. HAAs are …

Polymorphisms in the N-acetyltransferase 2 (NAT2) gene are determinants of the rate of
metabolic activation of carcinogenic compounds such as aryl aromatic amines …

The dietary mutagens 2-amino-3, 8-dimethylimidazo [4, 5-f] quinoxaline (MeIQx) and 2-
amino-1-methyl-6-phenylimidazo [4, 5-b] pyridine (PhIP) are activated to genotoxins by rat …

Many chemical carcinogens require metabolic activation via xenobiotic-metabolizing
enzymes in order to exert their genotoxic effects. Evidence from numerous in-vitro studies …

It seems to be satisfactorily proved that reactive oxygen species (ROS) participate in
numerous pathological processes in the nervous system (NS). Compounds able to interfere …

A metal-free [2+ 2+ 2] cycloaddition of alkyne-cyanamides or ynamide-nitriles with ynamides
is described for the efficient synthesis of amino-substituted α-and δ-carbolines. This novel …