Eukaryotic life depends on the spatial and temporal organization of cellular membrane
systems. Recent advances in understanding the machinery of vesicle transport have …

Common themes are emerging from the study of viral, cell-cell, intracellular, and liposome
fusion. Viral and cellular membrane fusion events are mediated by fusion proteins or fusion …

The endoplasmic reticulum (ER) of the yeast Saccharomyces cerevisiae contains of
proteolytic system able to selectively degrade misfolded lumenal secretory proteins. For …

Background: Sulfatases catalyze the hydrolysis of sulfuric acid esters from a wide variety of
substrates including glycosaminoglycans, glycolipids and steroids. There is sufficient …

Cathepsin D (EC 3.4. 23.5) is a lysosomal protease suspected to play important roles in
protein catabolism, antigen processing, degenerative diseases, and breast cancer …

Thrombospondin-1 (TSP-1) is a multidomain protein that has been implicated in cell
adhesion, motility, and growth. Some of these functions have been localized to the three …

The X-ray structure of the homotetrameric lysosomal acid hydrolase, human β-
glucuronidase (332,000 M r), has been determined at 2.6 Å resolution. The tetramer has …

The endoplasmic reticulum (ER) is a major protein folding compartment for secreted, plasma
membrane and organelle proteins. Each of these newly-synthesized polypeptides folds in a …

A novel clathrin adaptor-like complex, adaptor protein (AP)-3, has recently been described
in yeast and in animals. To gain insight into the role of yeast AP-3, a genetic strategy was …

Lectin-carbohydrate recognition between the selectins and their ligands are among the
earliest events in leukocyte recirculation, leukocyte recruitment into inflamed areas, and …