Retinal development and maturation are orchestrated by a series of interacting signalling
networks that drive the morphogenetic transformation of the anterior developing brain …

Recent advances have driven the development of stem cell-derived, self-organizing, three-
dimensional miniature organs, termed organoids, which mimic different eye tissues …

To study the development of the human retina, we use single-cell RNA sequencing (RNA-
seq) at key fetal stages and follow the development of the major cell types as well as …

A major cause for vision impairment and blindness in industrialized countries is the loss of
the light-sensing retinal tissue in the eye. Photoreceptor damage is one of the main …

Immunologically-matched, induced pluripotent stem cell (iPSC)-derived photoreceptor
precursor cells have the potential to restore vision to patients with retinal degenerative …

Self-organization is a process that ensures histogenesis of the eye retina. This highly
intricate phenomenon is not sufficiently studied due to its biological complexity and genetic …

Mammalian retinal metabolism favors aerobic glycolysis. However, the role of glycolytic
metabolism in retinal morphogenesis remains unknown. We report that aerobic glycolysis is …

The protocol outlined below is used to differentiate human pluripotent stem cells (hPSCs)
into retinal cell types through a process that faithfully recapitulates the stepwise progression …

Summary The X-linked DDX3X gene encodes an ATP-dependent DEAD-box RNA helicase
frequently altered in various human cancers, including melanomas. Despite its important …

Human eye development is coordinated through an extensive network of genetic signalling
pathways. Disruption of key regulatory genes in the early stages of eye development can …