The biological applications of DNA nanomaterials: current challenges and future directions
W Ma, Y Zhan, Y Zhang, C Mao, X Xie… - Signal transduction and …, 2021 - nature.com
DNA, a genetic material, has been employed in different scientific directions for various
biological applications as driven by DNA nanotechnology in the past decades, including …
biological applications as driven by DNA nanotechnology in the past decades, including …
Molecular imaging: design mechanism and bioapplications
Molecular imaging is a non-invasive method to image and analyze the concentration and
activity of functional biomolecules in cells or in vivo at molecular level, and plays an …
activity of functional biomolecules in cells or in vivo at molecular level, and plays an …
Discovery of aptamers targeting the receptor-binding domain of the SARS-CoV-2 spike glycoprotein
Y Song, J Song, X Wei, M Huang, M Sun… - Analytical …, 2020 - ACS Publications
The World Health Organization has declared the outbreak of a novel coronavirus (SARS-
CoV-2 or 2019-nCoV) as a global pandemic. However, the mechanisms behind the …
CoV-2 or 2019-nCoV) as a global pandemic. However, the mechanisms behind the …
Enhanced in vivo blood–brain barrier penetration by circular Tau–transferrin receptor bifunctional aptamer for tauopathy therapy
The lack of blood–brain barrier (BBB) penetrating ability has hindered the delivery of many
therapeutic agents for tauopathy treatment. In this study, we report the synthesis of a circular …
therapeutic agents for tauopathy treatment. In this study, we report the synthesis of a circular …
Hypoxia-activated PEGylated conditional aptamer/antibody for cancer imaging with improved specificity
F Zhou, T Fu, Q Huang, H Kuai, L Mo… - Journal of the …, 2019 - ACS Publications
Aptamers and antibodies, as molecular recognition probes, play critical roles in cancer
diagnosis and therapy. However, their recognition ability is based on target overexpression …
diagnosis and therapy. However, their recognition ability is based on target overexpression …
Rationally designed multivalent aptamers targeting cell surface for biomedical applications
Specific interactions between ligands and receptors on cell surface play an important role in
the cell biological process. Nucleic acid aptamers as commonly used ligands enable …
the cell biological process. Nucleic acid aptamers as commonly used ligands enable …
Structure-guided engineering of aptamers to enhanced structural stability and application performance in alleviating β-lactoglobulin allergenicity
Aptamers are synthetic single-strand oligonucleotide-based ligands with great application
potential due to their intriguing properties of specific and high affinity target binding and …
potential due to their intriguing properties of specific and high affinity target binding and …
Aptamers for SARS‐CoV‐2: Isolation, Characterization, and Diagnostic and Therapeutic Developments
The SARS‐CoV‐2 virus and COVID‐19 pandemic continue to demand effective diagnostic
and therapeutic solutions. Finding these solutions requires highly functional molecular …
and therapeutic solutions. Finding these solutions requires highly functional molecular …
Engineering of nucleic acids and synthetic cofactors as holo sensors for probing signaling molecules in the cellular membrane microenvironment
G Feng, X Luo, X Lu, S Xie, L Deng, W Kang… - Angewandte …, 2019 - Wiley Online Library
The comprehensive understanding of the mechanisms underlying the interaction of cells
with their membrane microenvironment is of great value for fundamental biological research; …
with their membrane microenvironment is of great value for fundamental biological research; …
Screening of a High-Affinity Aptamer for Aflatoxin M1 and Development of Its Colorimetric Aptasensor
X Wei, P Ma, K Imran Mahmood… - Journal of Agricultural …, 2023 - ACS Publications
Aflatoxin M1 (AFM1), a secondary metabolite of Aspergillus spp., is highly toxic and widely
present in food matrices. Therefore, the detection of AFM1 is of great importance for the …
present in food matrices. Therefore, the detection of AFM1 is of great importance for the …