The biological applications of DNA nanomaterials: current challenges and future directions

W Ma, Y Zhan, Y Zhang, C Mao, X Xie… - Signal transduction and …, 2021 - nature.com
DNA, a genetic material, has been employed in different scientific directions for various
biological applications as driven by DNA nanotechnology in the past decades, including …

Molecular imaging: design mechanism and bioapplications

L Chen, Y Lyu, X Zhang, L Zheng, Q Li, D Ding… - Science China …, 2023 - Springer
Molecular imaging is a non-invasive method to image and analyze the concentration and
activity of functional biomolecules in cells or in vivo at molecular level, and plays an …

Discovery of aptamers targeting the receptor-binding domain of the SARS-CoV-2 spike glycoprotein

Y Song, J Song, X Wei, M Huang, M Sun… - Analytical …, 2020 - ACS Publications
The World Health Organization has declared the outbreak of a novel coronavirus (SARS-
CoV-2 or 2019-nCoV) as a global pandemic. However, the mechanisms behind the …

Enhanced in vivo blood–brain barrier penetration by circular Tau–transferrin receptor bifunctional aptamer for tauopathy therapy

X Li, Y Yang, H Zhao, T Zhu, Z Yang, H Xu… - Journal of the …, 2020 - ACS Publications
The lack of blood–brain barrier (BBB) penetrating ability has hindered the delivery of many
therapeutic agents for tauopathy treatment. In this study, we report the synthesis of a circular …

Hypoxia-activated PEGylated conditional aptamer/antibody for cancer imaging with improved specificity

F Zhou, T Fu, Q Huang, H Kuai, L Mo… - Journal of the …, 2019 - ACS Publications
Aptamers and antibodies, as molecular recognition probes, play critical roles in cancer
diagnosis and therapy. However, their recognition ability is based on target overexpression …

Rationally designed multivalent aptamers targeting cell surface for biomedical applications

M Lin, J Zhang, H Wan, C Yan, F Xia - ACS Applied Materials & …, 2020 - ACS Publications
Specific interactions between ligands and receptors on cell surface play an important role in
the cell biological process. Nucleic acid aptamers as commonly used ligands enable …

Structure-guided engineering of aptamers to enhanced structural stability and application performance in alleviating β-lactoglobulin allergenicity

S Qi, X Dong, S Niazi, M Lu, N Duan, Z Wang - Chemical Engineering …, 2023 - Elsevier
Aptamers are synthetic single-strand oligonucleotide-based ligands with great application
potential due to their intriguing properties of specific and high affinity target binding and …

Aptamers for SARS‐CoV‐2: Isolation, Characterization, and Diagnostic and Therapeutic Developments

R Amini, Z Zhang, J Li, J Gu, JD Brennan… - Analysis & …, 2022 - Wiley Online Library
The SARS‐CoV‐2 virus and COVID‐19 pandemic continue to demand effective diagnostic
and therapeutic solutions. Finding these solutions requires highly functional molecular …

Engineering of nucleic acids and synthetic cofactors as holo sensors for probing signaling molecules in the cellular membrane microenvironment

G Feng, X Luo, X Lu, S Xie, L Deng, W Kang… - Angewandte …, 2019 - Wiley Online Library
The comprehensive understanding of the mechanisms underlying the interaction of cells
with their membrane microenvironment is of great value for fundamental biological research; …

Screening of a High-Affinity Aptamer for Aflatoxin M1 and Development of Its Colorimetric Aptasensor

X Wei, P Ma, K Imran Mahmood… - Journal of Agricultural …, 2023 - ACS Publications
Aflatoxin M1 (AFM1), a secondary metabolite of Aspergillus spp., is highly toxic and widely
present in food matrices. Therefore, the detection of AFM1 is of great importance for the …