Signalling pathways in autism spectrum disorder: mechanisms and therapeutic implications

CC Jiang, LS Lin, S Long, XY Ke, K Fukunaga… - Signal transduction and …, 2022 - nature.com
Autism spectrum disorder (ASD) is a prevalent and complex neurodevelopmental disorder
which has strong genetic basis. Despite the rapidly rising incidence of autism, little is known …

SHANK proteins: roles at the synapse and in autism spectrum disorder

P Monteiro, G Feng - Nature Reviews Neuroscience, 2017 - nature.com
Several large-scale genomic studies have supported an association between cases of
autism spectrum disorder and mutations in the genes SH3 and multiple ankyrin repeat …

Autism spectrum disorder: neuropathology and animal models

M Varghese, N Keshav, S Jacot-Descombes… - Acta …, 2017 - Springer
Autism spectrum disorder (ASD) has a major impact on the development and social
integration of affected individuals and is the most heritable of psychiatric disorders. An …

A synaptic perspective of fragile X syndrome and autism spectrum disorders

C Bagni, RS Zukin - Neuron, 2019 - cell.com
Altered synaptic structure and function is a major hallmark of fragile X syndrome (FXS),
autism spectrum disorders (ASDs), and other intellectual disabilities (IDs), which are …

A standardized social preference protocol for measuring social deficits in mouse models of autism

B Rein, K Ma, Z Yan - Nature protocols, 2020 - nature.com
Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by social
communication deficits and other behavioral abnormalities. The three-chamber social …

Anterior cingulate cortex dysfunction underlies social deficits in Shank3 mutant mice

B Guo, J Chen, Q Chen, K Ren, D Feng, H Mao… - Nature …, 2019 - nature.com
Social deficit is a core clinical feature of autism spectrum disorder (ASD) but the underlying
neural mechanisms remain largely unclear. We demonstrate that structural and functional …

Dysfunction of cortical GABAergic neurons leads to sensory hyper-reactivity in a Shank3 mouse model of ASD

Q Chen, CA Deister, X Gao, B Guo, T Lynn-Jones… - Nature …, 2020 - nature.com
Hyper-reactivity to sensory input is a common and debilitating symptom in individuals with
autism spectrum disorders (ASD), but the neural basis underlying sensory abnormality is not …

Social deficits in Shank3-deficient mouse models of autism are rescued by histone deacetylase (HDAC) inhibition

L Qin, K Ma, ZJ Wang, Z Hu, E Matas, J Wei… - Nature neuroscience, 2018 - nature.com
Haploinsufficiency of the SHANK3 gene is causally linked to autism spectrum disorder
(ASD), and ASD-associated genes are also enriched for chromatin remodelers. Here we …

Multiregion neuronal activity: the forest and the trees

TA Machado, IV Kauvar, K Deisseroth - Nature Reviews Neuroscience, 2022 - nature.com
The past decade has witnessed remarkable advances in the simultaneous measurement of
neuronal activity across many brain regions, enabling fundamentally new explorations of the …

Brain-wide electrical spatiotemporal dynamics encode depression vulnerability

R Hultman, K Ulrich, BD Sachs, C Blount, DE Carlson… - Cell, 2018 - cell.com
Brain-wide fluctuations in local field potential oscillations reflect emergent network-level
signals that mediate behavior. Cracking the code whereby these oscillations coordinate in …