Ergosterol is an essential component of fungal cell membranes that determines the fluidity,
permeability and activity of membrane-associated proteins. Ergosterol biosynthesis is a …

The XRN family of 5′→ 3′ exoribonucleases is critical for ensuring the fidelity of cellular
RNA turnover in eukaryotes. Highly conserved across species, the family is typically …

Stress granules (SGs) are cytoplasmic aggregates of stalled translational preinitiation
complexes that accumulate during stress. GW bodies/processing bodies (PBs) are distinct …

The control of mRNA stability is an important process that allows cells to not only limit, but
also rapidly adjust, the expression of regulatory factors whose over expression may be …

The degradation of eukaryotic mRNAs plays important roles in the modulation of gene
expression, quality control of mRNA biogenesis and antiviral defenses. In the past five years …

Although mRNA decay rates are a key determinant of the steady-state concentration for any
given mRNA species, relatively little is known, on a population level, about what factors …

Post-transcriptional processes have a central role in the regulation of eukaryotic gene
expression. Although it has been known for a long time that these processes are functionally …

AU-rich elements (AREs) in the 3′ untranslated region (UTR) of unstable mRNAs dictate
their degradation. An RNAi-based screen performed in Drosophila S2 cells has revealed …

Cancer‐related gene expression programs are strongly influenced by posttranscriptional
mechanisms. The RNA‐binding protein HuR is highly abundant in many cancers. Numerous …

The exosome complex of 3′→ 5′ exonucleases is an important component of the RNA-
processing machinery in eukaryotes. This complex functions in the accurate processing of …