A novel ultra-short-acting benzodiazepine (BDZ), remimazolam (CNS 7056), has been
designed by 'soft drug'development to achieve a better sedative profile than that of the …

A program to identify novel intravenous sedatives with a short and predictable duration of
action was initiated in the late 1990's by Glaxo Wellcome. The program focussed on the …

Background The effects of spinal anesthesia as compared with general anesthesia on the
ability to walk in older adults undergoing surgery for hip fracture have not been well studied …

Background: Remimazolam (CNS 7056) is a new ultra–short-acting benzodiazepine for
intravenous sedation and anesthesia. Its pharmacokinetics and pharmacodynamics have …

Background Patients with major depressive disorder (MDD) having active suicidal ideation
with intent require immediate treatment. Methods This double-blind study (ASPIRE II) …

Background Elderly patients with major depression have a poorer prognosis, are less
responsive to treatment, and show greater functional decline compared with younger …

European Society of Anaesthesiology and European Board of An... : European Journal of
Anaesthesiology | EJA European Society of Anaesthesiology and European Board of …

The safe sedation of children for procedures requires a systematic approach that includes
the following: no administration of sedating medication without the safety net of …

The number of diagnostic and minor surgical procedures performed on pediatric patients
outside of the traditional operating room setting has increased in the past several decades …

Unconsciousness is a fundamental component of general anesthesia (GA), but
anesthesiologists have no reliable ways to be certain that a patient is unconscious. To …