CX3CL1/CX3CR1 signaling targets for the treatment of neurodegenerative diseases

MS Subbarayan, A Joly-Amado, PC Bickford… - Pharmacology & …, 2022 - Elsevier
Neuroinflammation was initially thought of as a consequence of neurodegenerative disease
pathology, but more recently it is becoming clear that it plays a significant role in the …

[HTML][HTML] Mesenchymal stem cell secretome and extracellular vesicles for neurodegenerative diseases: Risk-benefit profile and next steps for the market access

L Giovannelli, E Bari, C Jommi, F Tartara, D Armocida… - Bioactive Materials, 2023 - Elsevier
Neurodegenerative diseases represent a growing burden on healthcare systems worldwide.
Mesenchymal stem cells (MSCs) have shown promise as a potential therapy due to their …

The microbiota–gut–brain axis in Huntington's disease: pathogenic mechanisms and therapeutic targets

MN Ekwudo, C Gubert, AJ Hannan - The FEBS Journal, 2024 - Wiley Online Library
Huntington's disease (HD) is a currently incurable neurogenerative disorder and is typically
characterized by progressive movement disorder (including chorea), cognitive deficits …

Tau: A biomarker of Huntington's disease

E Lepinay, F Cicchetti - Molecular Psychiatry, 2023 - nature.com
Developing effective treatments for patients with Huntington's disease (HD)—a
neurodegenerative disorder characterized by severe cognitive, motor and psychiatric …

Endocannabinoid modulation in neurodegenerative diseases: In pursuit of certainty

A Vasincu, RN Rusu, DC Ababei, M Larion, W Bild… - Biology, 2022 - mdpi.com
Simple Summary Neurodegenerative diseases represent an important cause of morbidity
and mortality worldwide. Existing therapeutic options are limited and focus mostly on …

PPARs and their neuroprotective effects in Parkinson's disease: a novel therapeutic approach in α-synucleinopathy?

I Pérez-Segura, A Santiago-Balmaseda… - International Journal of …, 2023 - mdpi.com
Parkinson's disease (PD) is the most common α-synucleinopathy worldwide. The
pathognomonic hallmark of PD is the misfolding and propagation of the α-synuclein (α-syn) …

The role of microglia in the development of neurodegenerative diseases

JW Lee, W Chun, HJ Lee, SM Kim, JH Min, DY Kim… - Biomedicines, 2021 - mdpi.com
Microglia play an important role in the maintenance and neuroprotection of the central
nervous system (CNS) by removing pathogens, damaged neurons, and plaques. Recent …

Recent developments in the management of Huntington's disease

SJ Devadiga, SS Bharate - Bioorganic Chemistry, 2022 - Elsevier
Huntington's disease (HD) is a rare, incurable, inherited neurodegenerative disorder
manifested by chorea, hyperkinetic, and hypokinetic movements. The FDA has approved …

New insight on microglia activation in neurodegenerative diseases and therapeutics

Y Xu, W Gao, Y Sun, M Wu - Frontiers in Neuroscience, 2023 - frontiersin.org
Microglia are immune cells within the central nervous system (CNS) closely linked to brain
health and neurodegenerative diseases such as Alzheimer's disease and Parkinson's …

Impact of the renin-angiotensin system on the pathogeny and pharmacotherapeutics of neurodegenerative diseases

W Bild, A Vasincu, RN Rusu, DC Ababei, AB Stana… - Biomolecules, 2022 - mdpi.com
Brain neurodegenerative diseases (BND) are debilitating conditions that are especially
characteristic of a certain period of life and considered major threats to human health …