Hematopoietic stem cells (HSCs) sustain blood cell production throughout the mammalian
life span. However, it has become clear that at the single cell level a subset of HSCs is stably …

Inflammation is a key driver of the progression of pre-leukemic myeloid conditions, such as
clonal hematopoiesis of indeterminate potential (CHIP) and clonal cytopenia of …

Acute myeloid leukemia (AML) is a deadly hematopoietic malignancy. Although many
patients achieve complete remission with standard induction therapy, a combination of …

In this issue, Waarts and colleagues developed an advanced ex vivo CRISPR screening
platform to identify vulnerabilities in clonal hematopoiesis (CH). This unique system allowed …

The liver is a highly regenerative organ capable of significant proliferation and remodeling
during homeostasis and injury responses. Experiments of nature in rare genetic diseases …

Hypertension impacts more than a billion people worldwide and is a risk factor for a wide
range of age-related diseases, including heart and kidney conditions. Hypertension itself …

Chronic myelomonocytic leukemia (CMML) is an aggressive clonal stem cell disorder
categorized among myelodysplastic/myeloproliferative overlap neoplasms. While sharing …

Simple Summary The expansion of mutant cells that outgrow and displace normal blood
cells is called clonal hematopoiesis (CH). CH starts with the acquisition of mutations in blood …

In this review, we introduce the concept of cell competition, which occurs between
heterogeneous neighboring cell populations. Cells with higher relative fitness become …

Clonal hematopoiesis involves mutations in hematopoietic stem/progenitor cells, which
increase the risk of cardiovascular disease, particularly under pro-inflammatory conditions …