Metals are essential for life, and they play a central role in the struggle between infecting
microbes and their hosts. In fact, an important aspect of microbial pathogenesis is the …

The ability of pathogenic microorganisms to assimilate sufficient nutrients for growth within
their hosts is a fundamental requirement for pathogenicity. However, certain trace nutrients …

Nutritional immunity describes the host-driven manipulation of essential micronutrients,
including iron, zinc and manganese. To withstand nutritional immunity and proliferate within …

Zinc is an essential nutrient for all organisms because this metal serves as a critical
structural or catalytic cofactor for many proteins. These zinc-dependent proteins are …

Blastomyces dermatitidis is a human fungal pathogen of the lung that can lead to
disseminated disease in healthy and immunocompromised individuals. Genetic analysis of …

Pathogenic microorganisms often face acute micronutrient limitation during infection due to
the action of host-mediated nutritional immunity. The human fungal pathogen Candida …

Due to lifespan extension and changes in global climate, the increase in mycoses caused by
primary and opportunistic fungal pathogens is now a global concern. Despite increasing …

All living organisms require certain micronutrients such as iron, zinc, manganese and
copper for cellular function and growth. For human pathogens however, the maintenance of …

Zinc is an essential nutrient for all living organisms. However, firm regulation must be
maintained since micronutrients also can be toxic in high concentrations. This notion is …

Histoplasma capsulatum (Hc) exists in the soil and is capable of adapting to the shift in
environment during infection to ensure survival. Yeast encounter a restrictive host …