Mechanisms of doxorubicin-mediated reproductive toxicity–a review
The anticancer drug doxorubicin has been associated with several adverse side-effects
including reproductive toxicity in both genders. The current review has complied the …
including reproductive toxicity in both genders. The current review has complied the …
Zika virus infection damages the testes in mice
J Govero, P Esakky, SM Scheaffer, E Fernandez… - Nature, 2016 - nature.com
Infection of pregnant women with Zika virus (ZIKV) can cause congenital malformations
including microcephaly, which has focused global attention on this emerging pathogen. In …
including microcephaly, which has focused global attention on this emerging pathogen. In …
[HTML][HTML] Multigenerational and transgenerational effects of dioxins
M Viluksela, R Pohjanvirta - International journal of molecular sciences, 2019 - mdpi.com
Dioxins are ubiquitous and persistent environmental contaminants whose background
levels are still reason for concern. There is mounting evidence from both epidemiological …
levels are still reason for concern. There is mounting evidence from both epidemiological …
[HTML][HTML] A live-attenuated Zika virus vaccine candidate induces sterilizing immunity in mouse models
Zika virus (ZIKV) infection of pregnant women can cause a wide range of congenital
abnormalities, including microcephaly, in the infant, a condition now collectively known as …
abnormalities, including microcephaly, in the infant, a condition now collectively known as …
[HTML][HTML] Triptonide is a reversible non-hormonal male contraceptive agent in mice and non-human primates
Z Chang, W Qin, H Zheng, K Schegg, L Han… - Nature …, 2021 - nature.com
There are no non-hormonal male contraceptives currently on the market despite decades of
efforts toward the development of “male pills”. Here, we report that triptonide, a natural …
efforts toward the development of “male pills”. Here, we report that triptonide, a natural …
Indoles from commensal bacteria extend healthspan
Multiple studies have identified conserved genetic pathways and small molecules
associated with extension of lifespan in diverse organisms. However, extending lifespan …
associated with extension of lifespan in diverse organisms. However, extending lifespan …
Cardamonin, a natural flavone, alleviates inflammatory bowel disease by the inhibition of NLRP3 inflammasome activation via an AhR/Nrf2/NQO1 pathway
K Wang, Q Lv, Y Miao, S Qiao, Y Dai, Z Wei - Biochemical pharmacology, 2018 - Elsevier
The present study aimed to evaluate the anti-colitis effect and underlying mechanisms of
cardamonin, a natural flavone isolated from Alpinia katsumadai Hayata. The results showed …
cardamonin, a natural flavone isolated from Alpinia katsumadai Hayata. The results showed …
[HTML][HTML] A single-dose live-attenuated vaccine prevents Zika virus pregnancy transmission and testis damage
Zika virus infection during pregnancy can cause congenital abnormities or fetal demise. The
persistence of Zika virus in the male reproductive system poses a risk of sexual …
persistence of Zika virus in the male reproductive system poses a risk of sexual …
Aryl hydrocarbon receptor as a target for lycopene preventing DEHP-induced spermatogenic disorders
Y Zhao, J Lin, M Talukder, SY Zhu, MZ Li… - Journal of agricultural …, 2020 - ACS Publications
Di (2-ethylhexyl) phthalate (DEHP) is widely used as a plasticizer to improve product
flexibility and workability. Lycopene (LYC) is a natural compound and has promising …
flexibility and workability. Lycopene (LYC) is a natural compound and has promising …
Human antibodies to the dengue virus E-dimer epitope have therapeutic activity against Zika virus infection
E Fernandez, W Dejnirattisai, B Cao, SM Scheaffer… - Nature …, 2017 - nature.com
The Zika virus (ZIKV) epidemic has resulted in congenital abnormalities in fetuses and
neonates. Although some cross-reactive dengue virus (DENV)-specific antibodies can …
neonates. Although some cross-reactive dengue virus (DENV)-specific antibodies can …