Mechanisms of doxorubicin-mediated reproductive toxicity–a review

UP Mohan, TP PB, STA Iqbal, S Arunachalam - Reproductive Toxicology, 2021 - Elsevier
The anticancer drug doxorubicin has been associated with several adverse side-effects
including reproductive toxicity in both genders. The current review has complied the …

Zika virus infection damages the testes in mice

J Govero, P Esakky, SM Scheaffer, E Fernandez… - Nature, 2016 - nature.com
Infection of pregnant women with Zika virus (ZIKV) can cause congenital malformations
including microcephaly, which has focused global attention on this emerging pathogen. In …

[HTML][HTML] Multigenerational and transgenerational effects of dioxins

M Viluksela, R Pohjanvirta - International journal of molecular sciences, 2019 - mdpi.com
Dioxins are ubiquitous and persistent environmental contaminants whose background
levels are still reason for concern. There is mounting evidence from both epidemiological …

[HTML][HTML] A live-attenuated Zika virus vaccine candidate induces sterilizing immunity in mouse models

C Shan, AE Muruato, BTD Nunes, H Luo, X Xie… - Nature medicine, 2017 - nature.com
Zika virus (ZIKV) infection of pregnant women can cause a wide range of congenital
abnormalities, including microcephaly, in the infant, a condition now collectively known as …

[HTML][HTML] Triptonide is a reversible non-hormonal male contraceptive agent in mice and non-human primates

Z Chang, W Qin, H Zheng, K Schegg, L Han… - Nature …, 2021 - nature.com
There are no non-hormonal male contraceptives currently on the market despite decades of
efforts toward the development of “male pills”. Here, we report that triptonide, a natural …

Indoles from commensal bacteria extend healthspan

R Sonowal, A Swimm, A Sahoo, L Luo… - Proceedings of the …, 2017 - National Acad Sciences
Multiple studies have identified conserved genetic pathways and small molecules
associated with extension of lifespan in diverse organisms. However, extending lifespan …

Cardamonin, a natural flavone, alleviates inflammatory bowel disease by the inhibition of NLRP3 inflammasome activation via an AhR/Nrf2/NQO1 pathway

K Wang, Q Lv, Y Miao, S Qiao, Y Dai, Z Wei - Biochemical pharmacology, 2018 - Elsevier
The present study aimed to evaluate the anti-colitis effect and underlying mechanisms of
cardamonin, a natural flavone isolated from Alpinia katsumadai Hayata. The results showed …

[HTML][HTML] A single-dose live-attenuated vaccine prevents Zika virus pregnancy transmission and testis damage

C Shan, AE Muruato, BW Jagger, J Richner… - Nature …, 2017 - nature.com
Zika virus infection during pregnancy can cause congenital abnormities or fetal demise. The
persistence of Zika virus in the male reproductive system poses a risk of sexual …

Aryl hydrocarbon receptor as a target for lycopene preventing DEHP-induced spermatogenic disorders

Y Zhao, J Lin, M Talukder, SY Zhu, MZ Li… - Journal of agricultural …, 2020 - ACS Publications
Di (2-ethylhexyl) phthalate (DEHP) is widely used as a plasticizer to improve product
flexibility and workability. Lycopene (LYC) is a natural compound and has promising …

Human antibodies to the dengue virus E-dimer epitope have therapeutic activity against Zika virus infection

E Fernandez, W Dejnirattisai, B Cao, SM Scheaffer… - Nature …, 2017 - nature.com
The Zika virus (ZIKV) epidemic has resulted in congenital abnormalities in fetuses and
neonates. Although some cross-reactive dengue virus (DENV)-specific antibodies can …