Pyruvate is the end-product of glycolysis, a major substrate for oxidative metabolism, and a
branching point for glucose, lactate, fatty acid and amino acid synthesis. The mitochondrial …

Silymarin is the extract of Silybum marianum, or milk thistle, and its major active compound
is silybin, which has a remarkable biological effect. It is used in different liver disorders …

Silymarin (SM), an extract from the Silybum marianum (milk thistle) plant containing various
flavonolignans (with silybin being the major one), has received a tremendous amount of …

Cardiac ATP production primarily depends on oxidative phosphorylation in mitochondria
and is dynamically regulated by Ca 2+ levels in the mitochondrial matrix as well as by …

Metabolic syndrome describes a complex metabolic risk factors including obesity,
hypertension, dyslipidemia, and diabetes. This syndrome is diagnosed by medical …

The only currently recommended treatment for nonalcoholic fatty liver disease (NAFLD) is
lifestyle modification. Preliminary studies of silybin showed beneficial effects on liver …

摘要背景对于糖尿病患者来说胰岛素抵抗与氧化应激是导致慢性肝病的主要致病因素.
肥沙鼠是一种独特的与人类疾病相似的营养性糖尿病模型. 这项研究在肥胖的沙鼠中调查了目前 …

Diabetes mellitus (DM) is a metabolic disorder disease, and the number of diabetic patients
will reach 578 million by 2030 predictably. Currently, 8 classes of small molecular drugs are …

Nowadays, the nonalcoholic fatty liver disease represents the main chronic liver disease in
the Western countries, and the correct medical therapy remains a big question for the …

Bone is a highly vascularized tissue that relies on a close spatial and temporal interaction
between blood vessels and bone cells. As a result, angiogenesis is critical for bone …