Proteinase‐activated receptors (PARs) are a four‐member family of G protein‐coupled
receptors defined by their irreversible proteolytic mechanism of activation. PARs have …

In recent years, targeted therapies have raised increasing interest as effective strategies to
improve therapeutic efficiency, reduce the impact of adverse side effects, and overcome …

Abstract Protease-activated receptor-2 (PAR2) is involved in inflammatory responses and
pain, therefore representing a promising therapeutic target for the treatment of immune …

Protease-activated receptor 2 (PAR2) is a cell surface protein linked to G-protein dependent
and independent intracellular signaling pathways that produce a wide range of …

Protease activated receptor 2 (PAR2) is associated with metabolism, obesity, inflammatory,
respiratory and gastrointestinal disorders, pain, cancer, and other diseases. The …

Introduction: Protease activated receptor 2 (PAR2) is a self-activated G protein-coupled
receptor that has been implicated in several diseases, including inflammatory …

Cancers affecting women, such as breast, uterine, ovarian, endometrial and cervical
cancers, have become increasingly prevalent. The growing incidence and death rates …

The proteolytically-activated G protein-coupled receptor (GPCR) protease-activated receptor
2 (PAR2), is implicated in various cancers and inflammatory diseases. Synthetic ligands and …

The vast array of G-protein-coupled receptors (GPCRs) play crucial roles in both
physiological and pathological processes, including vision, coagulation, inflammation …

Glucagon-like peptide-1 (GLP-1) signaling through the glucagon-like peptide 1 receptor
(GLP-1R) is a key regulator of normal glucose metabolism, and exogenous GLP-1R agonist …