Monocytes are innate blood cells that maintain vascular homeostasis and are early
responders to pathogens in acute infections. There are three well-characterized classes of …

Inflammatory monocytes and tissue-resident macrophages are key regulators of tissue
repair, regeneration, and fibrosis. After tissue injury, monocytes and macrophages undergo …

Cytokine storm generates during various systemic acute infections, including sepsis and
current pandemic called COVID-19 (severe) causing devastating inflammatory conditions …

Phagocytes form a family of immune cells that play a crucial role in tissue maintenance and
help orchestrate the immune response. This family of cells can be separated by their nuclear …

Cytokine release syndrome (CRS) is a life-threatening complication of several new
immunotherapies used to treat cancers and autoimmune diseases,,,–. Here we report that …

Abstract The Janus Kinase/Signal Transducers and Activators of Transcription (JAK/STAT)
signaling pathway is utilized by numerous cytokines and interferons, and is essential for the …

Multiple sclerosis is a chronic inflammatory disease of the central nervous system.
Astrocytes are heterogeneous glial cells that are resident in the central nervous system and …

Six healthy young male volunteers at a contract research organization were enrolled in the
first phase 1 clinical trial of TGN1412, a novel superagonist anti-CD28 monoclonal antibody …

Macrophages originating from the yolk sac or bone marrow play essential roles in tissue
homeostasis and disease. Bone marrow-derived monocytes differentiate into Ly6Chi and …

Lactic acid has emerged as an important modulator of immune cell function. It can be
produced by both gut microbiota and the host metabolism at homeostasis and during …