Mitochondria are central organelles in the homeostasis of the cardiovascular system via the
integration of several physiological processes, such as ATP generation via oxidative …

The free-living, non-parasitic nematode Caenorhabditis elegans is a premier model
organism for the study of aging and longevity due to its short lifespan, powerful genetic tools …

Mitochondrial biosynthesis regulated by the PGC-1α-NRF1-TFAM pathway is considered a
novel potential therapeutic target to treat heart failure (HF). Perindopril (PER) is an …

The use of angiotensin-converting enzyme inhibitors (ACEis) has been reported to reduce
symptoms of cognitive decline in patients with Alzheimer's disease (AD). Yet, the protective …

Angiotensin-converting enzyme (ACE) and its homologue ACE2 are key regulators of the
renin-angiotensin system and thereby cardiovascular function through their zinc …

Background Heart disease is a frequent cause of hospitalization and mortality for elderly
patients. A common feature of both heart disease and aging itself is the involvement of …

Physical resiliency declines with age and comorbid conditions. In humans, angiotensin-
converting enzyme (ACE) has been associated with attenuation of the decline in physical …

Background We investigated the pleiotropic effects of an angiotensin receptor-neprilysin
inhibitor (ARNi) on collateral-dependent myocardial perfusion in a rat model of coronary …

Evidence suggests that angiotensin-converting enzyme inhibitors (ACEIs) may increase
metabolic rate by promoting thermogenesis, potentially through enhanced fat oxidation and …

Exposure to alcohol has multiple effects on nervous system function, and organisms have
evolved mechanisms to optimally respond to the presence of ethanol. Sex differences in …