The current knowledge of the normal biochemistry of compounds that give rise to
resonances in human brain proton magnetic resonance spectra measureable at readily …

Background Cigarette smoking has been linked with both increased and decreased risk for
Alzheimer's disease (AD). This is relevant for the US military because the prevalence of …

Behavioral activities that require control over automatic routines typically feel effortful and
result in cognitive fatigue. Beyond subjective report, cognitive fatigue has been conceived as …

The Proton magnetic resonance (1H‐MRS) spectrum contains information about the
concentration of tissue metabolites within a predefined region of interest (a voxel). The …

We review the transport, synthesis and catabolism of glutathione in the brain as well as its
compartmentation and biochemistry in different brain cells. The major reactions involving …

Proton NMR spectroscopy is emerging from translational and preclinical neuroscience
research as an important tool for evidence based diagnosis and therapy monitoring. It …

Purpose: To evaluate the reproducibility of γ‐amino‐butyric acid (GABA) and glutamate
concentrations derived using three different spectral fitting methods, and to investigate …

Glutathione (GSH) serves as an important anti-oxidant in the brain by scavenging harmful
reactive oxygen species that are generated during different molecular processes. The GSH …

Spectral editing in in vivo 1H‐MRS provides an effective means to measure low‐
concentration metabolite signals that cannot be reliably measured by conventional MRS …

At the high field strength of 7 T, in vivo spectra of the human brain with exceptional spectral
quality sufficient to quantify 16 metabolites have been obtained previously only in the …