Fat accumulation outside subcutaneous adipose tissue often has unfavourable effects on
systemic metabolism. In addition to non-alcoholic fatty liver disease, which has received …

Obesity is increasingly prevalent and is associated with substantial cardiovascular risk.
Adipose tissue distribution and morphology play a key role in determining the degree of …

Aims/hypothesis Pancreatic fat accumulation may contribute to the development of beta cell
dysfunction. Exercise training improves whole-body insulin sensitivity, but its effects on …

Pancreatic cancer is typically detected at an advanced stage, and is refractory to most forms
of treatment, contributing to poor survival outcomes. The incidence of pancreatic cancer is …

Fat accumulation in the pancreas associated with obesity and the metabolic syndrome
(MetS) has been defined as “non-alcoholic fatty pancreas disease”(NAFPD). The aim of this …

Background Adiposity has been previously associated with cognitive impairment and
Alzheimer's disease and related disorders (ADRD). Body mass index (BMI) is the most …

Background It is now generally accepted that obesity is a major risk factor for type 2 diabetes
mellitus (T2DM). Hepatic steatosis in particular, as well as visceral and ectopic fat …

Adipose cells have traditionally been viewed as a simple, passive energy storage depot for
triglycerides. However, in recent years it has become clear that adipose cells are highly …

Obesity is the major contributing factor for the increased prevalence of type 2 diabetes (T2D)
in recent years. Sustained positive influx of lipids is considered to be a precipitating factor for …

The association between pancreatic fat, obesity and metabolic disease is well-documented,
and although a potentially exciting target for novel therapies, remains poorly understood …