DAF-16, the only forkhead box transcription factors class O (FoxO) homolog in
Caenorhabditis elegans, integrates signals from upstream pathways to elicit transcriptional …

While aging was traditionally viewed as a stochastic process of damage accumulation, it is
now clear that aging is strongly influenced by genetics. The identification and …

We propose a two-mode (pursuit/maintenance) model of metabolism defined by usable
resource availability. Pursuit, consisting of anabolism and catabolism, dominates when …

While mitochondrial function is essential for life in all multicellular organisms, a mild
impairment of mitochondrial function can extend longevity in model organisms. By …

Aspirin and curcumin have been reported to be beneficial to anti-aging in a variety of
biological models. Here, we synthesized a novel compound, curcumin acetylsalicylate (CA) …

During aging, preservation of locomotion is generally considered an indicator of sustained
good health, in elderlies and in animal models. In Caenorhabditis elegans, mutants of the …

Exposure to adverse nutritional and metabolic environments during critical periods of
development can exert long-lasting effects on health outcomes of an individual and its …

Mitochondria are dynamic organelles that can change shape and size depending on the
needs of the cell through the processes of mitochondrial fission and fusion. In this work, we …

Abstract Changes in the proteome of different human tissues with advancing age are poorly
characterized. Here, we studied the proteins present in primary skin fibroblasts collected …

Transcription factor EB (TFEB) is a conserved master transcriptional activator of autophagy
and lysosomal genes that modulates organismal lifespan regulation and stress resistance …