Pathogenesis of human immunodeficiency virus infection

JA Levy - Microbiological reviews, 1993 - Am Soc Microbiol
The lentivirus human immunodeficiency virus (HIV) causes AIDS by interacting with a large
number of different cells in the body and escaping the host immune response against it. HIV …

Microglia and cytokines in neurological disease, with special reference to AIDS and Alzheimer's disease

DW Dickson, SC Lee, LA Mattiace, SHC Yen… - Glia, 1993 - Wiley Online Library
Microglia are associated with central nervous system (CNS) pathology of both Alzheimer's
disease (AD) and the acquired immunodeficiency syndrome (AIDS). In AD, microglia …

[图书][B] HIV and the pathogenesis of AIDS.

JA Levy - 1994 - cabidigitallibrary.org
This book grew out of a scientific review, originally published in Microbiological Reviews. It
has been updated and expanded-now citing more than 2100 references (100 pages of the …

Identification of the envelope V3 loop as the primary determinant of cell tropism in HIV-1

SS Hwang, TJ Boyle, HK Lyerly, BR Cullen - Science, 1991 - science.org
Cells of the monocyte-macrophage lineage are targets for human immunodeficiency virus-1
(HIV-1) infection in vivo. However, many laboratory strains of HIV-1 that efficiently infect …

Cellular reservoirs of HIV-1 and their role in viral persistence

A Alexaki, Y Liu, B Wigdahl - Current HIV research, 2008 - ingentaconnect.com
A major obstacle in human immunodeficiency virus type 1 (HIV-1) eradication is the ability of
the virus to remain latent in a subpopulation of the cells it infects. Latently infected cells can …

Molecular targets for AIDS therapy

H Mitsuya, R Yarchoan, S Broder - Science, 1990 - science.org
The development of antiretroviral therapy against acquired immunodeficiency syndrome
(AIDS) has been an intense research effort since the discovery of the causative agent …

Sequence and expression of a membrane-associated C-type lectin that exhibits CD4-independent binding of human immunodeficiency virus envelope glycoprotein …

BM Curtis, S Scharnowske… - Proceedings of the …, 1992 - National Acad Sciences
The binding of the human immunodeficiency virus (HIV) envelope glycoprotein gp120 to the
cell surface receptor CD4 has been considered a primary determinant of viral tropism. A …

Cells of the central nervous system as targets and reservoirs of the human immunodeficiency virus

S Kramer-Hämmerle, I Rothenaigner, H Wolff, JE Bell… - Virus research, 2005 - Elsevier
The availability of highly active antiretroviral therapies (HAART) has not eliminated HIV-1
infection of the central nervous system (CNS) or the occurrence of HIV-associated …

High concentrations of recombinant soluble CD4 are required to neutralize primary human immunodeficiency virus type 1 isolates.

ES Daar, XL Li, T Moudgil… - Proceedings of the …, 1990 - National Acad Sciences
There is substantial evidence supporting the CD4 molecule as the principal cellular receptor
for the human immunodeficiency virus type 1 (HIV-1). A number of truncated recombinant …

Inhibition of entry of HIV-1 in neural cell lines by antibodies against galactosyl ceramide

JM Harouse, S Bhat, SL Spitalnik, M Laughlin… - Science, 1991 - science.org
Although the CD4 molecule is the principal cellular receptor for the human
immunodeficiency virus (HIV), several CD4-negative cell lines are susceptible to infection …