The nitric oxide-guanylate cyclase pathway and glaucoma
Glaucoma is a prevalent optic neuropathy characterized by the progressive dysfunction and
loss of retinal ganglion cells (RGCs) and their optic nerve axons, which leads to irreversible …
loss of retinal ganglion cells (RGCs) and their optic nerve axons, which leads to irreversible …
The role of sildenafil in treating brain injuries in adults and neonates
Y Xiong, P Wintermark - Frontiers in Cellular Neuroscience, 2022 - frontiersin.org
Sildenafil is a recognized treatment for patients suffering from erectile dysfunction and
pulmonary hypertension. However, new evidence suggests that it may have a …
pulmonary hypertension. However, new evidence suggests that it may have a …
A novel role of Nano selenium and sildenafil on streptozotocin-induced diabetic nephropathy in rats by modulation of inflammatory, oxidative, and apoptotic pathways
Aims The present study aimed to investigate the effect of nano selenium, sildenafil, and their
combination on inflammation, oxidative stress, and apoptosis in streptozotocin-induced …
combination on inflammation, oxidative stress, and apoptosis in streptozotocin-induced …
Sildenafil during pregnancy: a preclinical meta-analysis on fetal growth and maternal blood pressure
ND Paauw, F Terstappen, W Ganzevoort, JA Joles… - …, 2017 - Am Heart Assoc
Sildenafil is a new approach to treat fetal growth restriction (FGR) and preeclampsia. We
performed a systematic meta-analysis to evaluate effects of sildenafil. Our search identified …
performed a systematic meta-analysis to evaluate effects of sildenafil. Our search identified …
Avanafil mitigates testicular ischemia/reperfusion injury via NLRP3 pathway modulation in rats
M Celik, P Aydin, MS Civelek, N Akgun, Z Karakoy… - Reproductive …, 2024 - Springer
Objective: In our study, the effectiveness of avanafil, a second-generation
phosphodiesterase-5 (PDE5) inhibitor, on testicular torsion (TT) related …
phosphodiesterase-5 (PDE5) inhibitor, on testicular torsion (TT) related …
Safety and dose‐finding trial of tadalafil administered for fetal growth restriction: a phase‐1 clinical study
M Kubo, H Tanaka, S Maki, M Nii… - Journal of Obstetrics …, 2017 - Wiley Online Library
Aim We designed a safety and dose‐finding trial of tadalafil administered for fetal growth
restriction (FGR). Methods Three cases were initially commenced on 10 mg/day and …
restriction (FGR). Methods Three cases were initially commenced on 10 mg/day and …
[HTML][HTML] Erectile dysfunction drugs and oxidative stress in the liver of male rats
Erectile dysfunction (ED) affected the lives of more than 300 million men worldwide. Erectile
dysfunction drugs (EDD), known as phosphodiesterase inhibitors (PDEIs), have been used …
dysfunction drugs (EDD), known as phosphodiesterase inhibitors (PDEIs), have been used …
Protective effect of sildenafil on liver injury induced by intestinal ischemia/reperfusion
Background This study evaluated the protective effect of sildenafil on liver injury induced by
intestinal ischemia-reperfusion. Methods Forty female Sprague Dawley rats were divided …
intestinal ischemia-reperfusion. Methods Forty female Sprague Dawley rats were divided …
Sildenafil attenuates hepatocellular injury after liver ischemia reperfusion in rats: a preliminary study
S Savvanis, C Nastos, MK Tasoulis… - Oxidative medicine …, 2014 - Wiley Online Library
We evaluated the role of sildenafil in a rat liver ischemia‐reperfusion model. Forty male rats
were randomly allocated in four groups. The sham group underwent midline laparotomy …
were randomly allocated in four groups. The sham group underwent midline laparotomy …
Advancements in phosphodiesterase 5 inhibitors: unveiling present and future perspectives
Phosphodiesterase 5 (PDE5) inhibitors presented themselves as important players in the
nitric oxide/cGMP pathway, thus exerting a profound impact on various physiological and …
nitric oxide/cGMP pathway, thus exerting a profound impact on various physiological and …