Curcumin is a phytochemical isolated from Curcuma longa with potent tumor‐suppressor
activity, which has shown significant efficacy in pre‐clinical and clinical studies. Curcumin …

Despite advances in genetic and proteomic techniques, a complete portrait of the proteome
and its complement of dynamic interactions and modifications remains a lofty, and as of yet …

Itaconate has been recently recognized as an anti-inflammatory metabolite involved in the
pathogen–macrophage interface. Due to its weak electrophilicity, itaconate could modify …

Covering: 2010 up to 2016 Deconvoluting the mode of action of natural products and drugs
remains one of the biggest challenges in chemistry and biology today. Chemical proteomics …

Proteins are the most abundant biomolecules within a cell and are involved in all
biochemical cellular processes, fulfilling specific functions with unmatched precision. This …

Nature has a remarkable ability to carry out site-selective post-translational modification of
proteins, therefore enabling a marked increase in their functional diversity. Inspired by this …

This Perspective focuses on thiol-mediated uptake, that is, the entry of substrates into cells
enabled by oligochalcogenides or mimics, often disulfides, and inhibited by thiol-reactive …

Cysteine chemoproteomics provides proteome-wide portraits of the ligandability or potential"
druggability" for thousands of cysteine residues. Consequently, these studies are facilitating …

Hypervalent iodine compounds are privileged reagents in organic synthesis because of their
exceptional reactivity. Among these compounds, cyclic derivatives stand apart because of …

Phenotype-based screening has emerged as an alternative route for discovering new
chemical entities toward first-in-class therapeutics. However, clarifying their mode of action …