Rationale: Chronic obstructive pulmonary disease (COPD) is a complex disorder with high
mortality worldwide. Studies on the role of candidate genes and their polymorphisms in …

A genetic contribution to develop chronic obstructive pulmonary disease (COPD) is well
established. However, the specific genes responsible for enhanced risk or host differences …

Background: Cachexia is common in chronic obstructive pulmonary disease (COPD) and is
thought to be linked to an enhanced systemic inflammatory response. Objective: We …

Chronic obstructive pulmonary disease (COPD) is a common chronic inflammatory disease
with high morbidity and mortality rates worldwide. Cytokines, which are the main regulators …

Background Cyclic adenosine monophosphate (cAMP) levels are directly activated by
adenylate cyclase (AC) and play an anti-inflammatory role in chronic obstructive pulmonary …

Aim: To identify differentially methylated probes (DMPs) and regions (DMRs) in relation to
chronic obstructive pulmonary disease (COPD) and lung function traits. Methods: We …

The recognition of the importance of angiogenesis in tumor progression has led to the
development of antiangiogenesis as a new strategy for cancer treatment and prevention. By …

Tumour necrosis factor (TNF)-α has been shown to be an important factor in animal models
of chronic obstructive pulmonary disease (COPD). However, human studies of TNF …

Objective Chronic obstructive pulmonary disease (COPD) is a major health problem. The
disease is driven by abnormal inflammatory reactions in response to inhaled particles and …

Abstract The interleukin-1 (IL-1) gene polymorphisms have been implicated in chronic
obstructive pulmonary disease (COPD) risk, but results are controversial. We aimed to …