Drug delivery to the posterior eye segment is an important challenge in ophthalmology,
because many diseases affect the retina and choroid leading to impaired vision or …

Retinitis pigmentosa (RP) is the most common cause of inherited blindness and is
characterised by the progressive loss of retinal photoreceptors. However, RP is a highly …

Differential evolution of apoptosis, programmed necrosis, and autophagy, parthanatos is a
form of cell death mediated by poly (ADP-ribose) polymerase 1 (PARP1), which is caused by …

The cellular mechanisms underlying hereditary photoreceptor degeneration are still poorly
understood, a problem that is exacerbated by the enormous genetic heterogeneity of this …

Achromatopsia (ACHM), also known as rod monochromatism or total color blindness, is an
autosomal recessively inherited retinal disorder that affects the cones of the retina, the type …

Epigenetic regulation orchestrates many cellular processes and greatly influences key
disease mechanisms. Histone deacetylase (HDAC) enzymes play a crucial role either as …

Inherited retinal dystrophies (IRDs) are a large group of genetically and clinically
heterogeneous diseases characterized by the progressive degeneration of the retina …

Inherited retinal degeneration (RD) is a devastating and currently untreatable
neurodegenerative condition that leads to loss of photoreceptor cells and blindness. The …

The sphingolipids ceramide (Cer), sphingosine-1-phosphate (S1P), sphingosine (Sph), and
ceramide-1-phosphate (C1P) are key signaling molecules that regulate major cellular …

Studies utilizing large animal models of inherited retinal degeneration (IRD) have proven
important in not only the development of translational therapeutic approaches, but also in …