Abstract The 1, 2, 4-triazolo [1, 5-a] pyrimidine (TP) heterocycle, in spite of its relatively
simple structure, has proved to be remarkably versatile as evidenced by its use in many …

In this review, the synthesis of 33 agrochemicals that received an international
standardization organization (ISO) name between January 2015 and December 2018 is …

Abstract The [1, 2, 4] triazolo [1, 5-a] pyrimidines (TPs) comprise an important class of non-
naturally occurring small molecules that aroused the interest of researches. This scaffold is …

Trypanosoma brucei is a protozoan parasite that causes Human African Trypanosomiasis
(HAT), a neglected tropical disease (NTD) that is endemic in 36 countries in sub-Saharan …

Chagas disease is a major public health problem caused by Trypanosoma cruzi, with an
estimated 6–7 million people infected and 70 million at risk of infection. T. brucei gambiense …

The protozoa, Trypanosoma cruzi (etiological agent of Chagas diseases–also named
American trypanosomiasis) and T. brucei (causative agent of human African …

Parasitic infections are a major source of human suffering, mortality, and economic loss, but
drug development for these diseases has been stymied by the significant expense involved …

Tubulin and microtubules (MTs) are potential protein targets to treat parasitic infections and
our previous studies have shown that the triazolopyrimidine (TPD) class of MT‐active …

Abstract Design of tubulin inhibitors as anticancer drugs dynamically developed over the
past 20 years. The modern arsenal of potential tubulin-targeting anticancer agents is …

Background and objectives: Sleeping sickness and malaria alike are insect-borne protozoan
diseases that share overlapping endemic areas in sub-Saharan Africa. The causative agent …