Use of tyrosine kinase inhibitors to prevent relapse after allogeneic hematopoietic stem cell transplantation for patients with Philadelphia chromosome–positive acute …

S Giebel, A Czyz, O Ottmann, F Baron, E Brissot… - Cancer, 2016 - Wiley Online Library
Allogeneic hematopoietic stem cell transplantation (alloHSCT) is a standard of care for
patients with Philadelphia chromosome (Ph)–positive acute lymphoblastic leukemia (ALL) …

Acute lymphoblastic leukemia, version 2.2021, NCCN clinical practice guidelines in oncology

PA Brown, B Shah, A Advani, P Aoun… - Journal of the National …, 2021 - jnccn.org
The NCCN Guidelines for Acute Lymphoblastic Leukemia (ALL) focus on the classification of
ALL subtypes based on immunophenotype and cytogenetic/molecular markers; risk …

[HTML][HTML] Relapse prevention with tyrosine kinase inhibitors after allogeneic transplantation for philadelphia chromosome–positive acute lymphoblast leukemia: A …

Z Warraich, P Tenneti, T Thai, A Hubben, H Amin… - Biology of Blood and …, 2020 - Elsevier
Relapse after stem cell transplantation for Philadelphia chromosome–positive (Ph+) acute
lymphoblastic leukemia (ALL) remains a significant challenge. In this systematic review, we …

The role of allogeneic transplant for adult Ph+ ALL in CR1 with complete molecular remission: a retrospective analysis

A Ghobadi, M Slade, H Kantarjian… - Blood, The Journal …, 2022 - ashpublications.org
Abstract Historically, Philadelphia chromosome-positive (Ph+) acute lymphoblastic leukemia
(ALL) has been associated with poor outcomes, and allogeneic hematopoietic cell …

[HTML][HTML] Imatinib after induction for treatment of children and adolescents with Philadelphia-chromosome-positive acute lymphoblastic leukaemia (EsPhALL): a …

A Biondi, M Schrappe, P De Lorenzo, A Castor… - The lancet …, 2012 - thelancet.com
Background Trials of imatinib have provided evidence of activity in adults with Philadelphia-
chromosome-positive acute lymphoblastic leukaemia (ALL), but the drug's role when given …

[HTML][HTML] Tyrosine kinase inhibitors improve long-term outcome of allogeneic hematopoietic stem cell transplantation for adult patients with Philadelphia chromosome …

E Brissot, M Labopin, MM Beckers, G Socié… - …, 2015 - ncbi.nlm.nih.gov
This study aimed to determine the impact of tyrosine kinase inhibitors given pre-and post-
allogeneic stem cell transplantation on long-term outcome of patients allografted for …

IKZF1 status as a prognostic feature in BCR-ABL1–positive childhood ALL

A Van Der Veer, M Zaliova, F Mottadelli… - Blood, The Journal …, 2014 - ashpublications.org
Childhood BCR-ABL1–positive B-cell precursor acute lymphoblastic leukemia (BCP-ALL)
has an unfavorable outcome and shows high frequency of IKZF1 deletions. The prognostic …

[HTML][HTML] miR-145 antagonizes SNAI1-mediated stemness and radiation resistance in colorectal cancer

Y Zhu, C Wang, SA Becker, K Hurst, LM Nogueira… - Molecular Therapy, 2018 - cell.com
Epithelial-to-mesenchymal transition (EMT) has been closely linked with therapy resistance
and cancer stem cells (CSCs). However, EMT pathways have proven challenging to …

Ph+ ALL patients in first complete remission have similar survival after reduced intensity and myeloablative allogeneic transplantation: impact of tyrosine kinase …

V Bachanova, DI Marks, MJ Zhang, H Wang, M de Lima… - Leukemia, 2014 - nature.com
The efficacy of reduced intensity conditioning (RIC) allogeneic hematopoietic cell
transplantation (HCT) for Philadelphia chromosome positive (Ph+) acute lymphoblastic …

[HTML][HTML] Treatment of Philadelphia chromosome-positive acute lymphoblastic leukemia in adults

K Saleh, A Fernandez, F Pasquier - Cancers, 2022 - mdpi.com
Simple Summary Outcome of patients with Philadelphia-chromosome positive acute
lymphoblastic leukemia (Ph+ ALL) dramatically improved during the past 20 years with the …