Primary immune thrombocytopenic purpura (ITP) remains a diagnosis of exclusion both from
nonimmune causes of thrombocytopenia and immune thrombocytopenia that develops in …

Cytokines function as communication tools of the immune system, serving critical functions
in many biological responses and shaping the immune response. When cytokine production …

A variety of cytokines activate receptor-associated members of the Janus family of protein
tyrosine kinases (Jaks). To assess the role of Jak2, we have derived Jak2-deficient mice …

Background The cause of polycythemia vera, which originates from a multipotent
hematopoietic progenitor cell, is unknown. Thrombopoietin is a hematopoietic growth factor …

Thrombopoietin (TPO) is the cytokine that is chiefly responsible for megakaryocyte
production but increasingly attention has turned to its role in maintaining hematopoietic stem …

Hematopoietic stem cells (HSCs) play a key role in hematopoietic system that functions
mainly in homeostasis and immune response. HSCs transplantation has been applied for …

Events relayed via the single transmembrane receptor for erythropoietin (Epo) are essential
for the development of committed erythroid progenitor cells beyond the colony-forming unit …

The megakaryocytic (MK) and erythroid lineages are tightly associated during differentiation
and are generated from a bipotent megakaryocyte-erythroid progenitor (MEP). In the mouse …

The thrombopoietin receptor (TpoR) regulates hematopoietic stem cell renewal,
megakaryocyte differentiation, and platelet formation. TpoR signals by activating Janus …

Thrombopoietin (TPO) is a recently cloned cytokine that binds to its receptor, Mpl, and
promotes hematopoietic expansion and maturation, primarily of the megakaryocyte lineage …